爪哇田菁花二甲基亚砜提取物及其主要黄酮苷的抗诱变活性

Antimutagenic activity of Sesbania javanica Miq. flower DMSO extract and its major flavonoid glycoside.

作者信息

Tangvarasittichai Surapon, Sriprang Nimit, Harnroongroj Talabporn, Changbumrung Supranee

机构信息

Department of Tropical Nutrition and Food Science, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

出版信息

Southeast Asian J Trop Med Public Health. 2005 Nov;36(6):1543-51.

PMID:16610660

Abstract

The antimutagenic activity of Sesbania javanica Miq. or Sano, an edible vegetable flower DMSO extract against aflatoxin B1 (AFB1) benzo (a) pyrene [B(a)P], was evaluated by means of the Ames' test. The Sesbania javanica Miq. flower DMSO extract showed a strong inhibitory effect against AFB1 and B(a)P mutagens. A search to isolate the major flavonoid in Sesbania javanica Miq. flower extract found the flavonol glycoside, Quercetin 3-2(G)-rhamnosylrutinoside, which was confirmed by its physicochemical properties as a major constituent of the flower. Quercetin 3-2(G)-rhamnosylrutinoside (207 microg/plate) also showeda strong inhibitory effect against AFB1 and B(a)P with a more than 70% inhibition rate.

摘要

通过艾姆斯试验评估了可食用蔬菜花爪哇田菁（Sesbania javanica Miq. 或 Sano）二甲基亚砜提取物对黄曲霉毒素B1（AFB1）和苯并（a）芘 [B（a）P] 的抗诱变活性。爪哇田菁花二甲基亚砜提取物对AFB1和B（a）P诱变剂表现出强烈的抑制作用。对爪哇田菁花提取物中主要黄酮类化合物进行分离的研究发现了黄酮醇糖苷槲皮素3-2（G）-鼠李糖基芸香糖苷，通过其理化性质证实该化合物是花的主要成分。槲皮素3-2（G）-鼠李糖基芸香糖苷（207微克/平板）对AFB1和B（a）P也表现出强烈的抑制作用，抑制率超过70%。