澳大利亚双胞胎静息血压的遗传力与稳定性

Heritability and stability of resting blood pressure in Australian twins.

作者信息

Hottenga Jouke-Jan, Whitfield John B, de Geus Eco J C, Boomsma Dorret I, Martin Nicholas G

机构信息

Department of Biological Psychology and the Center for Neurogenomics and Clinical Research, Vrije Universiteit, Amsterdam, the Netherlands.

出版信息

Twin Res Hum Genet. 2006 Apr;9(2):205-9. doi: 10.1375/183242706776382455.

DOI:10.1375/183242706776382455

PMID:16611489

Abstract

In Australian twins participating in three different studies (1979-1996), the contribution of genetic and environmental influences to variation in resting systolic (SBP) and diastolic blood pressure (DBP) was studied. The sample consisted of 368 monozygotic and 335 dizygotic twin pairs with measurements for both individuals. Blood pressure measurements in two studies were available for 115 complete twin pairs, and 49 twin pairs had measurements in three studies. This allowed assessment of blood pressure tracking over an average period of 12 years in the age range of 23 to 45 years. Multivariate analyses showed significant heritability (h2) of blood pressure in all studies (SBP h2 = 19%-56%, DBP h2 = 37%-52%). In addition, the analyses showed that the blood pressure tracking was explained by the same set of genetic factors. These results replicate an earlier finding in Dutch twins that also showed stability of the contribution of genetic factors to blood pressure tracking.

摘要

在参与三项不同研究（1979 - 1996年）的澳大利亚双胞胎中，研究了遗传和环境因素对静息收缩压（SBP）和舒张压（DBP）变异的影响。样本包括368对同卵双胞胎和335对异卵双胞胎，两人均有测量数据。两项研究中有115对完整双胞胎的血压测量数据，三项研究中有49对双胞胎的测量数据。这使得能够评估23至45岁年龄段平均12年期间的血压追踪情况。多变量分析显示，所有研究中血压均具有显著遗传性（h2）（SBP h2 = 19% - 56%，DBP h2 = 37% - 52%）。此外，分析表明，血压追踪可以由同一组遗传因素来解释。这些结果重复了荷兰双胞胎早期的一项发现，该发现也表明遗传因素对血压追踪的贡献具有稳定性。