Fellman Johan, Eriksson Aldur W
Folkhälsan Institute of Genetics, Population Genetics Unit, Helsinki, Finland.
Twin Res Hum Genet. 2006 Apr;9(2):260-5. doi: 10.1375/183242706776382356.
The temporal variation in the stillbirth rates (SBR), measured as the number of stillborn per 1000 total births, among singletons, twins and triplets was studied on Swedish birth data for the period 1869 to 2001 and comparisons with data from other populations were made. Among both single and multiple births there were marked, almost monotonously decreasing trends in the stillbirth rates. Among singletons the stillbirth rate decreased from 29.5 per 1000 in the period 1869 to 1878 to 3.4 in the period 1991 to 2001. Among twins the stillbirth rate decreased from 94 per 1000 in 1869 to 1878 to a minimum of 8.2 in 1991 to 2001 and among triplets from 166 per 1000 to a minimum of 19.8. The relative declining pattern in the SBRs was almost the same, being 88% among singletons, 91% among twins and 88% among triplets. In the 1980s and 1990s the definition of the stillbirth rate was changed in many countries, including Finland, but no changes in the definition of stillbirths have been made in Sweden. The effect of the artificial reproduction techniques, including in vitro fertilization, on the rates of multiple maternities is also discussed. It was noted especially that they had a more marked effect on the triplet than on the twinning rate.
以每1000例总出生数中的死产数来衡量,对1869年至2001年瑞典出生数据中单胎、双胎和三胎的死产率(SBR)的时间变化进行了研究,并与其他人群的数据进行了比较。在单胎和多胎出生中,死产率均呈现出明显的、几乎单调下降的趋势。在单胎中,死产率从1869年至1878年期间的每1000例29.5例降至1991年至2001年期间的3.4例。在双胎中,死产率从1869年至1878年的每1000例94例降至1991年至2001年的最低8.2例,在三胎中从每1000例166例降至最低19.8例。死产率的相对下降模式几乎相同,单胎中为88%,双胎中为91%,三胎中为88%。在20世纪80年代和90年代,包括芬兰在内的许多国家改变了死产率的定义,但瑞典没有对死产的定义进行更改。还讨论了包括体外受精在内的人工生殖技术对多胎生育发生率的影响。特别值得注意的是,它们对三胎生育的影响比对双胎生育发生率的影响更为显著。