Cox Eric, Verdonck Frank, Vanrompay Daisy, Goddeeris Bruno
Laboratory of Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.
Vet Res. 2006 May-Jun;37(3):511-39. doi: 10.1051/vetres:2006014. Epub 2006 Apr 14.
In developing veterinary mucosal vaccines and vaccination strategies, mucosal adjuvants are one of the key players for inducing protective immune responses. Most of the mucosal adjuvants seem to exert their effect via binding to a receptor/or target cells and these properties were used to classify the mucosal adjuvants reviewed in the present paper: (1) ganglioside receptor-binding toxins (cholera toxin, LT enterotoxin, their B subunits and mutants); (2) surface immunoglobulin binding complex CTA1-DD; (3) TLR4 binding lipopolysaccharide; (4) TLR2-binding muramyl dipeptide; (5) Mannose receptor-binding mannan; (6) Dectin-1-binding ss 1,3/1,6 glucans; (7) TLR9-binding CpG-oligodeoxynucleotides; (8) Cytokines and chemokines; (9) Antigen-presenting cell targeting ISCOMATRIX and ISCOM. In addition, attention is given to two adjuvants able to prime the mucosal immune system following a systemic immunization, namely 1alpha, 25(OH)2D3 and cholera toxin.
在开发兽用黏膜疫苗和疫苗接种策略时，黏膜佐剂是诱导保护性免疫反应的关键因素之一。大多数黏膜佐剂似乎通过与受体/或靶细胞结合发挥作用，本文依据这些特性对所综述的黏膜佐剂进行了分类：(1)神经节苷脂受体结合毒素（霍乱毒素、LT肠毒素、它们的B亚基及突变体）；(2)表面免疫球蛋白结合复合物CTA1-DD；(3)TLR4结合脂多糖；(4)TLR2结合胞壁酰二肽；(5)甘露糖受体结合甘露聚糖；(6)Dectin-1结合的β1,3/1,6葡聚糖；(7)TLR9结合的CpG-寡脱氧核苷酸；(8)细胞因子和趋化因子；(9)靶向抗原呈递细胞的免疫刺激复合物（ISCOMATRIX）和免疫刺激复合物（ISCOM）。此外，还关注了两种在全身免疫后能够启动黏膜免疫系统的佐剂，即1α,25(OH)2D3和霍乱毒素。
