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Is kinetoplastid pan-editing the result of an evolutionary balancing act?

作者信息

Speijer Dave

机构信息

Department of Medical Biochemistry, AMC, Amsterdam, The Netherlands.

出版信息

IUBMB Life. 2006 Feb;58(2):91-6. doi: 10.1080/15216540600551355.

Abstract

Kinetoplastid U-insertion/deletion type editing is a highly elaborate process to generate translationally competent mitochondrial mRNAs. All evolutionary models to explain its origin and extent in present day organisms lack a convincing description of the advantage(s) responsible for an active increase of the editing potential. This advantage can be found in the gene fragmentation that is inherent in pan-editing which gives protection against loss of temporarily non expressed mitochondrial genes during periods of intense intraspecies competition.

摘要

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