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Does anti-tumour necrosis factor alpha treatment modify the tuberculin PPD response?抗肿瘤坏死因子α治疗是否会改变结核菌素纯蛋白衍生物（PPD）反应？
Ann Rheum Dis. 2006 May;65(5):699. doi: 10.1136/ard.2005.040055.
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Blocking TNF in vitro with infliximab determines the inhibition of expansion and interferon gamma production of Vgamma9/Vdelta2 T lymphocytes from patients with active rheumatoid arthritis. A role in the susceptibility to tuberculosis?在体外使用英夫利昔单抗阻断肿瘤坏死因子（TNF）可抑制活动性类风湿关节炎患者Vγ9/Vδ2 T淋巴细胞的扩增和干扰素γ的产生。这与结核病易感性有关吗？
Reumatismo. 2009 Jan-Mar;61(1):21-6. doi: 10.4081/reumatismo.2009.21.
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Unaffected reaction level in tuberculin skin test by long-term therapy with tumor necrosis factor inhibitors for rheumatoid arthritis.类风湿关节炎患者长期使用肿瘤坏死因子抑制剂治疗后结核菌素皮肤试验的无反应水平
Int J Rheum Dis. 2017 May;20(5):584-588. doi: 10.1111/1756-185X.13101. Epub 2017 May 19.
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Is it safe to use anti-TNF-α agents for tuberculosis in children suffering with chronic rheumatic disease?儿童慢性风湿性疾病患者使用抗 TNF-α 药物治疗结核是否安全？
Rheumatol Int. 2012 Sep;32(9):2675-9. doi: 10.1007/s00296-011-2030-8. Epub 2011 Jul 26.
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[Comprehension and prevention of infections using TNF inhibitors].
Rev Med Interne. 2005 Oct;26 Spec No 1:39-41.
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Tuberculosis infection in rheumatic patients with infliximab therapy: experience with 157 patients.类风湿关节炎患者接受英夫利昔单抗治疗后并发结核感染：157 例患者的经验。
Rheumatol Int. 2012 Sep;32(9):2769-75. doi: 10.1007/s00296-011-2017-5. Epub 2011 Aug 7.
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Low prevalence of reactive PPD prior to infliximab use: comparative study on a population sample of Hospital Geral de Fortaleza.英夫利昔单抗使用前反应性PPD的低患病率：福塔莱萨综合医院人群样本的比较研究
Rev Bras Reumatol. 2011 Jan-Feb;51(1):40-52.
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Tumour necrosis factor alpha inhibitors: screening for tuberculosis infection in inflammatory bowel disease.肿瘤坏死因子α抑制剂：炎症性肠病中结核感染的筛查
Med J Aust. 2008 Feb 4;188(3):168-70. doi: 10.5694/j.1326-5377.2008.tb01565.x.
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How frequently do tuberculosis screening tests convert in inflammatory bowel disease patients on anti-tumour necrosis factor-alpha? A pilot study.在接受抗肿瘤坏死因子-α治疗的炎症性肠病患者中，结核筛查试验的转化频率有多高？一项初步研究。
Dig Liver Dis. 2013 Sep;45(9):733-7. doi: 10.1016/j.dld.2013.03.005. Epub 2013 Apr 12.
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Infliximab does not suppress the tuberculin skin test (purified protein derivative).
J Rheumatol. 2007 Mar;34(3):474-80. Epub 2007 Feb 1.
引用本文的文献
1
Characterisation of the clinical and activated T cell response to repeat delayed-type hypersensitivity skin challenges in human subjects, with KLH and PPD, as a potential model to test T cell-targeted therapies.以钥孔戚血蓝蛋白（KLH）和结核菌素纯蛋白衍生物（PPD）对人类受试者进行重复迟发型超敏反应皮肤激发试验，以此作为测试T细胞靶向疗法的潜在模型，对临床及活化T细胞反应进行表征。
Inflamm Res. 2016 May;65(5):389-404. doi: 10.1007/s00011-016-0923-4. Epub 2016 Mar 11.
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TNF-alpha antagonist therapy modify the tuberculin skin test response.TNF-α拮抗剂治疗可改变结核菌素皮肤试验反应。
Rheumatol Int. 2011 Sep;31(9):1147-51. doi: 10.1007/s00296-010-1424-3. Epub 2010 Mar 27.
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Increased risk of tuberculosis in patients treated with antitumor necrosis factor alpha.接受抗肿瘤坏死因子α治疗的患者患结核病风险增加。
Clin Rheumatol. 2009 Apr;28(4):421-6. doi: 10.1007/s10067-008-1067-x. Epub 2008 Dec 4.
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Repeated tuberculin skin testing following therapy with TNF-alpha inhibitors.使用肿瘤坏死因子-α抑制剂治疗后进行重复结核菌素皮肤试验。
Clin Rheumatol. 2009 Feb;28(2):167-72. doi: 10.1007/s10067-008-1007-9. Epub 2008 Sep 16.
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Performance of two commercial blood IFN-gamma release assays for the detection of Mycobacterium tuberculosis infection in patient candidates for anti-TNF-alpha treatment.两种用于检测抗TNF-α治疗候选患者中结核分枝杆菌感染的商用血液干扰素-γ释放试验的性能
Eur J Clin Microbiol Infect Dis. 2008 Oct;27(10):907-13. doi: 10.1007/s10096-008-0519-1. Epub 2008 May 10.
本文引用的文献
1
TNF-alpha is a critical negative regulator of type 1 immune activation during intracellular bacterial infection.肿瘤坏死因子-α是细胞内细菌感染期间1型免疫激活的关键负调节因子。
J Clin Invest. 2004 Feb;113(3):401-13. doi: 10.1172/JCI18991.
2
Updated consensus statement on biological agents for the treatment of rheumatoid arthritis and other immune mediated inflammatory diseases (May 2003).关于治疗类风湿关节炎及其他免疫介导的炎性疾病的生物制剂的更新共识声明（2003年5月）
Ann Rheum Dis. 2003 Nov;62 Suppl 2(Suppl 2):ii2-9. doi: 10.1136/ard.62.suppl_2.ii2.
3
Treatment of rheumatoid arthritis with tumor necrosis factor inhibitors may predispose to significant increase in tuberculosis risk: a multicenter active-surveillance report.肿瘤坏死因子抑制剂治疗类风湿关节炎可能会使结核病风险显著增加：一项多中心主动监测报告。
Arthritis Rheum. 2003 Aug;48(8):2122-7. doi: 10.1002/art.11137.
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Role of cytokines in rheumatoid arthritis.细胞因子在类风湿关节炎中的作用。
Annu Rev Immunol. 1996;14:397-440. doi: 10.1146/annurev.immunol.14.1.397.
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Tumor necrosis factor-alpha is required in the protective immune response against Mycobacterium tuberculosis in mice.肿瘤坏死因子-α在小鼠抗结核分枝杆菌的保护性免疫反应中是必需的。
Immunity. 1995 Jun;2(6):561-72. doi: 10.1016/1074-7613(95)90001-2.
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Delayed cutaneous hypersensitivity in rheumatoid arthritis: the influence of nutrition and drug therapy.类风湿关节炎中的迟发性皮肤超敏反应：营养与药物治疗的影响
Clin Rheumatol. 1984 Mar;3(1):39-45. doi: 10.1007/BF02715694.
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Impaired delayed type cutaneous hypersensitivity in rheumatoid arthritis reversed by chrysotherapy.金疗法逆转类风湿关节炎中受损的迟发型皮肤超敏反应。
Ann Rheum Dis. 1989 Feb;48(2):108-13. doi: 10.1136/ard.48.2.108.
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