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2
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Variable constraints on the principal immunodominant domain of the transmembrane glycoprotein of human immunodeficiency virus type 1.对1型人类免疫缺陷病毒跨膜糖蛋白主要免疫显性结构域的可变限制
J Virol. 1999 Jul;73(7):5698-706. doi: 10.1128/JVI.73.7.5698-5706.1999.
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Role of envelope processing and gp41 membrane spanning domain in the formation of human immunodeficiency virus type 1 (HIV-1) fusion-competent envelope glycoprotein complex.包膜加工及gp41跨膜结构域在人类免疫缺陷病毒1型（HIV-1）融合活性包膜糖蛋白复合物形成中的作用
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本文引用的文献

1
Stoichiometry of envelope glycoprotein trimers in the entry of human immunodeficiency virus type 1.1型人类免疫缺陷病毒进入过程中包膜糖蛋白三聚体的化学计量学
J Virol. 2005 Oct;79(19):12132-47. doi: 10.1128/JVI.79.19.12132-12147.2005.
2
Identification of N-phenyl-N'-(2,2,6,6-tetramethyl-piperidin-4-yl)-oxalamides as a new class of HIV-1 entry inhibitors that prevent gp120 binding to CD4.鉴定N-苯基-N'-(2,2,6,6-四甲基哌啶-4-基)草酰胺为一类新型的HIV-1进入抑制剂，其可阻止gp120与CD4结合。
Virology. 2005 Sep 1;339(2):213-25. doi: 10.1016/j.virol.2005.06.008.
3
An unrelated monoclonal antibody neutralizes human immunodeficiency virus type 1 by binding to an artificial epitope engineered in a functionally neutral region of the viral envelope glycoproteins.一种无关的单克隆抗体通过与在病毒包膜糖蛋白功能中性区域设计的人工表位结合来中和1型人类免疫缺陷病毒。
J Virol. 2005 May;79(9):5616-24. doi: 10.1128/JVI.79.9.5616-5624.2005.
4
Stoichiometry of antibody neutralization of human immunodeficiency virus type 1.1型人类免疫缺陷病毒抗体中和的化学计量学
J Virol. 2005 Mar;79(6):3500-8. doi: 10.1128/JVI.79.6.3500-3508.2005.
5
The many mechanisms of viral membrane fusion proteins.病毒膜融合蛋白的多种机制。
Curr Top Microbiol Immunol. 2005;285:25-66. doi: 10.1007/3-540-26764-6_2.
6
Small-molecule inhibitors of HIV-1 entry block receptor-induced conformational changes in the viral envelope glycoproteins.HIV-1进入的小分子抑制剂可阻断受体诱导的病毒包膜糖蛋白构象变化。
Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):5036-41. doi: 10.1073/pnas.0307953101. Epub 2004 Mar 29.
7
A small molecule HIV-1 inhibitor that targets the HIV-1 envelope and inhibits CD4 receptor binding.一种靶向HIV-1包膜并抑制CD4受体结合的小分子HIV-1抑制剂。
Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):11013-8. doi: 10.1073/pnas.1832214100. Epub 2003 Aug 20.
8
Peptides trap the human immunodeficiency virus type 1 envelope glycoprotein fusion intermediate at two sites.肽在两个位点捕获1型人类免疫缺陷病毒包膜糖蛋白融合中间体。
J Virol. 2003 Feb;77(3):1666-71. doi: 10.1128/jvi.77.3.1666-1671.2003.
9
Identification of conserved and variable structures in the human immunodeficiency virus gp120 glycoprotein of importance for CXCR4 binding.鉴定人类免疫缺陷病毒gp120糖蛋白中对于与CXCR4结合至关重要的保守和可变结构。
J Virol. 2002 Nov;76(21):10791-800. doi: 10.1128/jvi.76.21.10791-10800.2002.
10
The stoichiometry of trimeric SIV glycoprotein interaction with CD4 differs from that of anti-envelope antibody Fab fragments.
J Biol Chem. 2001 Nov 16;276(46):42667-76. doi: 10.1074/jbc.M104166200. Epub 2001 Sep 5.

1型人类免疫缺陷病毒包膜糖蛋白三聚体在病毒进入宿主细胞过程中的亚基化学计量学

Subunit stoichiometry of human immunodeficiency virus type 1 envelope glycoprotein trimers during virus entry into host cells.

作者信息

Yang Xinzhen, Kurteva Svetla, Ren Xinping, Lee Sandra, Sodroski Joseph

机构信息

Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School, 44 Binney Street, JFB 824, Boston, Massachusetts 02115, USA.

出版信息

J Virol. 2006 May;80(9):4388-95. doi: 10.1128/JVI.80.9.4388-4395.2006.

DOI:10.1128/JVI.80.9.4388-4395.2006
PMID:16611898
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1472027/
Abstract

The envelope glycoproteins of human immunodeficiency virus type 1 (HIV-1) function as a homotrimer of gp120/gp41 heterodimers to support virus entry. During the process of virus entry, an individual HIV-1 envelope glycoprotein trimer binds the cellular receptors CD4 and CCR5/CXCR4 and mediates the fusion of the viral and the target cellular membranes. By studying the function of heterotrimers between wild-type and nonfunctional mutant envelope glycoproteins, we found that two wild-type subunits within an envelope glycoprotein trimer are required to support virus entry. Complementation between HIV-1 envelope glycoprotein mutants defective in different functions to allow virus entry was not evident. These results assist our understanding of the mechanisms whereby the HIV-1 envelope glycoproteins mediate virus entry and membrane fusion and guide attempts to inhibit these processes.

摘要

人类免疫缺陷病毒1型（HIV-1）的包膜糖蛋白作为gp120/gp41异二聚体的同源三聚体发挥作用，以支持病毒进入。在病毒进入过程中，单个HIV-1包膜糖蛋白三聚体结合细胞受体CD4和CCR5/CXCR4，并介导病毒膜与靶细胞膜的融合。通过研究野生型和无功能突变包膜糖蛋白之间的异三聚体功能，我们发现包膜糖蛋白三聚体内的两个野生型亚基是支持病毒进入所必需的。不同功能缺陷的HIV-1包膜糖蛋白突变体之间允许病毒进入的互补作用并不明显。这些结果有助于我们理解HIV-1包膜糖蛋白介导病毒进入和膜融合的机制，并指导抑制这些过程的尝试。