Boskey Adele L, Young Marian F, Kilts Tina, Verdelis Kostas
Mineralized Tissue Research Laboratory, Musculoskeletal Integrity Program, Hospital for Special Surgery, New York, NY 10021, USA.
Cells Tissues Organs. 2005;181(3-4):144-53. doi: 10.1159/000091376.
Hydroxyapatite mineral is deposited in an organized fashion in the matrices of bones and teeth. The amount of mineral present, the composition of the mineral, and the size of the mineral crystals varies with both tissue and animal age, diet, health status, and the tissue being examined. Here, we review methods for measuring these differences in mineral properties and provide some illustrations from bones and teeth of animals in which the small leucine-rich proteoglycans (biglycan and decorin) were ablated. Differences in mineral properties between biglycan-deficient bones and teeth are related to the functions of this small proteoglycan in these tissues.
羟基磷灰石矿物质以有组织的方式沉积在骨骼和牙齿的基质中。所存在的矿物质数量、矿物质组成以及矿物质晶体的大小会因组织和动物年龄、饮食、健康状况以及所检查的组织而有所不同。在此，我们综述了测量这些矿物质特性差异的方法，并提供了一些来自缺乏富含亮氨酸小分子蛋白聚糖（双糖链蛋白聚糖和核心蛋白聚糖）的动物骨骼和牙齿的示例。双糖链蛋白聚糖缺陷型骨骼和牙齿之间矿物质特性的差异与这种小分子蛋白聚糖在这些组织中的功能有关。
