骨连接蛋白在骨骼中的作用。
Biglycan in the Skeleton.
机构信息
Molecular Biology of Bones and Teeth Section, National Institutes of Dental and Craniofacial Research, National Institutes of Health, U.S. Department of Health & Human Services, Bethesda, Maryland.
Laboratory of Cardiogenetics, Center of Medical Genetics, University Hospital Antwerp, University of Antwerp, Antwerp, Belgium.
出版信息
J Histochem Cytochem. 2020 Nov;68(11):747-762. doi: 10.1369/0022155420937371. Epub 2020 Jul 6.
Abstract
Small leucine rich proteoglycans (SLRPs), including Biglycan, have key roles in many organ and tissue systems. The goal of this article is to review the function of Biglycan and other related SLRPs in mineralizing tissues of the skeleton. The review is divided into sections that include Biglycan's role in structural biology, signaling, craniofacial and long bone homeostasis, remodeled skeletal tissues, and in human genetics. While many cell types in the skeleton are now known to be affected by Biglycan, there are still unanswered questions about its mechanism of action(s).
摘要
小富含亮氨酸的蛋白聚糖 (SLRPs)，包括 biglycan，在许多器官和组织系统中具有关键作用。本文的目的是综述 biglycan 及其他相关 SLRPs 在骨骼矿化组织中的功能。综述分为几个部分，包括 biglycan 在结构生物学、信号转导、颅面骨和长骨稳态、重塑骨骼组织以及人类遗传学中的作用。虽然骨骼中的许多细胞类型现在都被认为受 biglycan 影响，但关于其作用机制仍有许多未解决的问题。
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