Kataoka Yoshiki, Nio Yoshinori, Yano Seiji, Koike Makoto, Hashimoto Koji, Itakura Masayuki, Itagaki Tomoko, Nishi Takeshi, Endo Shinichiro, Higami Tetsuya
Dept. of Cardiovascular and Digestive Surgery, Shimane University School of Medicine.
Gan To Kagaku Ryoho. 2006 Apr;33(4):525-8.
Pancreatic acinar cell carcinomas are rare, and little is reported on their chemotherapy. We report a 49-year old male patient with pancreatic acinar cell carcinoma and multiple liver metastases, which responded to oral TS-1 and hepatic arterial infusion of cisplatin. The patient underwent a partial hepatectomy, MCT abrasions and excision of the pancreatic tumor. Postoperative pathological studies revealed metastases of acinar cell carcinoma to the liver and lymph nodes; the primary lesion was undetermined. After surgery, the patient was treated with hepatic arterial infusion of cisplatin and oral TS-1. Metastatic tumors completely disappeared, and serum lipase decreased to normal levels. Abdominal CT one year after surgery revealed a pancreatic body tumor, which was surgically removed. Pathological studies showed primary pancreatic acinar cell carcinoma, while previous metastases remained under control. To summarize, TS-1 and cisplatin can be effective treatments for pancreatic acinar cell carcinomas.
胰腺腺泡细胞癌较为罕见，关于其化疗的报道较少。我们报告一例49岁男性胰腺腺泡细胞癌伴多发肝转移患者，该患者对口服替吉奥胶囊（TS-1）及肝动脉灌注顺铂治疗有反应。患者接受了部分肝切除术、微波固化消融术及胰腺肿瘤切除术。术后病理研究显示腺泡细胞癌转移至肝脏和淋巴结；原发灶未明确。术后，患者接受肝动脉灌注顺铂及口服TS-1治疗。转移瘤完全消失，血清脂肪酶降至正常水平。术后一年腹部CT显示胰体部肿瘤，遂行手术切除。病理研究显示为原发性胰腺腺泡细胞癌，而之前的转移灶仍处于可控状态。总之，TS-1和顺铂对胰腺腺泡细胞癌可能是有效的治疗方法。
