Oliveira Maria de Lourdes Aguiar, Hacker Mariana A, Oliveira Sabrina Alberti Nóbrega de, Telles Paulo Roberto, O Kycia Maria Rodrigues do, Yoshida Clara Fumiko Tachibana, Bastos Francisco I
Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Cad Saude Publica. 2006 Apr;22(4):861-70. doi: 10.1590/s0102-311x2006000400024. Epub 2006 Apr 5.
The context of first drug injection and its association with ongoing injecting practices and HCV (hepatitis C virus) infection were investigated. Injection drug users (IDUs) (N = 606) were recruited in "drug scenes" (public places, bars) in Rio de Janeiro, Brazil, interviewed, and tested for HCV. Sharing of needles/syringes was more prevalent at the first injection (51.3%) than at the baseline interview (36.8%). Those who shared syringes/needles at first injection were more likely to be currently engaged in direct/indirect sharing practices. Among young injectors (< 30 years), those reporting sharing of needles/ syringes at the first injection were about four times more likely to have been infected by HCV. Hepatitis C virus prevalence among active IDUs (n = 272) was 11%. Prison history and longer duration of drug injection were identified as independent predictors of HCV infection. To effectively curb HCV transmission among IDUs and minimize harms associated with risk behaviors, preventive strategies should target individuals initiating drug injection beginning with their very first injection and discourage the transition from non-injecting use to the self-injection of illicit drugs.
研究了首次注射毒品的背景及其与持续注射行为和丙型肝炎病毒（HCV）感染的关联。在巴西里约热内卢的“毒品场所”（公共场所、酒吧）招募了606名注射吸毒者（IDU），对他们进行访谈并检测HCV。首次注射时共用针头/注射器的情况（51.3%）比基线访谈时（36.8%）更为普遍。首次注射时共用注射器/针头的人目前更有可能参与直接/间接共用行为。在年轻注射者（<30岁）中，那些报告首次注射时共用针头/注射器的人感染HCV的可能性约为四倍。活跃的注射吸毒者（n = 272）中丙型肝炎病毒感染率为11%。有入狱史和更长的吸毒注射时间被确定为HCV感染的独立预测因素。为了有效遏制注射吸毒者中的HCV传播并尽量减少与危险行为相关的危害，预防策略应针对刚开始注射毒品的个人，从他们首次注射开始，并劝阻从非注射吸毒向自行注射非法药物的转变。
