Whitmore Lee, Janes Robert W, Wallace B A
Dept. of Crystallography, Birkbeck College, University of London, London, UK.
Chirality. 2006 Jun;18(6):426-9. doi: 10.1002/chir.20267.
The Protein Circular Dichroism Data Bank (PCDDB) is a new deposition data bank for validated circular dichroism spectra of biomacromolecules. Its aim is to be a resource for the structural biology and bioinformatics communities, providing open access and archiving facilities for circular dichroism and synchrotron radiation circular dichroism spectra. It is named in parallel with the Protein Data Bank (PDB), a long-existing valuable reference data bank for protein crystal and NMR structures. In this article, we discuss the design of the data bank structure and the deposition website located at http://pcddb.cryst.bbk.ac.uk. Our aim is to produce a flexible and comprehensive archive, which enables user-friendly spectral deposition and searching. In the case of a protein whose crystal structure and sequence are known, the PCDDB entry will be linked to the appropriate PDB and sequence data bank files, respectively. It is anticipated that the PCDDB will provide a readily accessible biophysical catalogue of information on folded proteins that may be of value in structural genomics programs, for quality control and archiving in industrial and academic labs, as a resource for programs developing spectroscopic structural analysis methods, and in bioinformatics studies.
蛋白质圆二色性数据库（PCDDB）是一个用于存储经过验证的生物大分子圆二色性光谱的新数据库。其目标是成为结构生物学和生物信息学领域的一个资源库，为圆二色性光谱和同步辐射圆二色性光谱提供开放获取和存档设施。它与蛋白质数据库（PDB）并行命名，PDB是一个长期存在的、关于蛋白质晶体和核磁共振结构的有价值的参考数据库。在本文中，我们讨论了位于http://pcddb.cryst.bbk.ac.uk的数据库结构和存档网站的设计。我们的目标是创建一个灵活且全面的存档库，以实现用户友好的光谱存档和检索。对于晶体结构和序列已知的蛋白质，PCDDB条目将分别链接到相应的PDB和序列数据库文件。预计PCDDB将提供一个易于获取的关于折叠蛋白的生物物理信息目录，这在结构基因组学计划中可能具有价值，可用于工业和学术实验室的质量控制和存档，作为开发光谱结构分析方法的计划的资源，以及用于生物信息学研究。
