Schlatter E
Physiologisches Institut, Universität Freiburg.
Klin Wochenschr. 1991 Sep 3;69(13):610-7. doi: 10.1007/BF01649324.
In the following, factors will be discussed which regulate the ionic conductances of the luminal membrane of principal cells of the cortical collecting duct. Transport of sodium and potassium, which is mediated via selective sodium- and potassium-channels, is chronically or acutely adjusted to the needs of the salt balance by the hormones aldosterone and adiuretin. In addition, the potassium conductance and thus potassium secretion can be modified by the cellular pH, which results in a direct and reciprocal coupling between potassium and proton excretion in the cortical collecting duct.
接下来,将讨论调节皮质集合管主细胞管腔膜离子电导的因素。通过选择性钠通道和钾通道介导的钠和钾转运,会由醛固酮和抗利尿激素根据盐平衡的需求进行长期或急性调节。此外,细胞内pH可改变钾电导,进而影响钾分泌,这导致皮质集合管中钾排泄与质子排泄之间存在直接的相互偶联关系。