Seki Koji, Sumino Hiroyuki, Nara Misa, Ishiyama Nobuyoshi, Nishino Michio, Murakami Masami
Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan.
Clin Hemorheol Microcirc. 2006;34(3):401-10.
We investigated the relationships between blood rheology assessed by microchannel method and the various hemorheologic factors in healthy subjects. One hundred seventy-six healthy volunteers (90 men and 86 women, mean age; 32.9+/-11.3 years) were participated in this study. Body weight, body mass index, red blood cell count, hematocrit, hemoglobin, white blood cell count, and platelet count, plasma fibrinogen, and fasting serum lipid and lipoprotein concentrations were measured. In order to assess blood rheology, blood passage time was determined by a microchannel method (Micro Channel Array Flow Analyzer). Age, body mass index, red blood cell count, hematocrit, hemoglobin, white blood cell count, total cholesterol, low-density lipoprotein cholesterol, and triglyceride were positively correlated with blood passage time in all subjects, respectively (p<0.01) and high-density lipoprotein cholesterol was inversely correlated with blood passage time (p<0.01). However, platelet count, and fibrinogen were not correlated with blood passage time. The present study showed that increased age, body mass index, red blood cell count, white blood cell count, total cholesterol, low-density lipoprotein cholesterol, and triglyceride and decreased high-density lipoprotein cholesterol were associated with impaired blood rheology measured by microchannel method in healthy subjects, suggesting that aging, obesity, erythrocytosis, leukocytosis, and dyslipidemia may be related to hemorheological disorders. This microchannel method may be useful to study blood rheology which may be associated with various risk factors of cardiovascular disorders.
我们研究了通过微通道法评估的血液流变学与健康受试者各种血液流变学因素之间的关系。176名健康志愿者（90名男性和86名女性，平均年龄32.9±11.3岁）参与了本研究。测量了体重、体重指数、红细胞计数、血细胞比容、血红蛋白、白细胞计数、血小板计数、血浆纤维蛋白原以及空腹血清脂质和脂蛋白浓度。为了评估血液流变学，采用微通道法（微通道阵列流动分析仪）测定血液通过时间。在所有受试者中，年龄、体重指数、红细胞计数、血细胞比容、血红蛋白、白细胞计数、总胆固醇、低密度脂蛋白胆固醇和甘油三酯分别与血液通过时间呈正相关（p<0.01），而高密度脂蛋白胆固醇与血液通过时间呈负相关（p<0.01）。然而，血小板计数和纤维蛋白原与血液通过时间无关。本研究表明，在健康受试者中，年龄增加、体重指数升高、红细胞计数增加、白细胞计数增加、总胆固醇升高、低密度脂蛋白胆固醇升高和甘油三酯升高以及高密度脂蛋白胆固醇降低与通过微通道法测量的血液流变学受损有关，提示衰老、肥胖、红细胞增多症、白细胞增多症和血脂异常可能与血液流变学紊乱有关。这种微通道法可能有助于研究与心血管疾病各种危险因素相关的血液流变学。
