Faculty of Education, Kogakkan University, Ise, Mie, Japan.
Clin Appl Thromb Hemost. 2010 Aug;16(4):414-21. doi: 10.1177/1076029609339745. Epub 2009 Jul 24.
The reference values of blood rheology in healthy participants, especially children, are not available. The purpose of this study was to determine the blood passage time (BPT) as an index of blood rheology, in healthy children and adults, using the microchannel array flow analyzer, and to investigate the hematological factors that define BPT.
Participants were 61 healthy children (35 boys, 26 girls; age 5-6 years) and 71 healthy adults (24 men, age 35.2 +/- 14.1 years; 47 women, age 44.7 +/- 14.1 years, mean +/- standard deviation [SD]). Blood passage time and various hematological variables (blood cell count, serum lipids, and fibrinogen) were measured and compared among the 4 study groups.
Blood passage time values were significantly higher in adult men (48.8 +/- 5.8 seconds) than in boys (41.9 +/- 4.0 seconds), girls (43.7 +/- 7.8 seconds), and adult women (42.4 +/- 4.8 seconds). Stepwise regression analysis identified erythrocyte count and hemoglobin (Hb) as the significant and independent determinants of BPT (P < .05).
Our study demonstrates that BPT is significantly longer in healthy adult men than in adult women and children, and that erythrocyte count and Hb are significant determinants of blood rheology.
健康参与者（尤其是儿童）的血液流变学参考值尚不清楚。本研究旨在使用微通道阵列流分析仪确定血液通过时间（BPT）作为血液流变学指标，并探讨定义 BPT 的血液学因素。
研究对象为 61 名健康儿童（男 35 名，女 26 名；年龄 5-6 岁）和 71 名健康成年人（男 24 名，年龄 35.2±14.1 岁；女 47 名，年龄 44.7±14.1 岁，均为均值±标准差）。测量并比较了 4 组研究对象的 BPT 和各种血液学变量（血细胞计数、血脂和纤维蛋白原）。
成年男性的 BPT 值（48.8±5.8 秒）明显高于男孩（41.9±4.0 秒）、女孩（43.7±7.8 秒）和成年女性（42.4±4.8 秒）。逐步回归分析确定红细胞计数和血红蛋白（Hb）是 BPT 的显著独立决定因素（P<.05）。
本研究表明，健康成年男性的 BPT 明显长于成年女性和儿童，红细胞计数和 Hb 是血液流变学的重要决定因素。
