一项关于随机停止阴道灌洗后阴道菌群变化的试点研究。
A pilot study of vaginal flora changes with randomization to cessation of douching.
作者信息
Klebanoff Mark A, Andrews William W, Yu Kai Fun, Brotman Rebecca M, Nansel Tonja R, Zhang Jun, Cliver Suzanne P, Schwebke Jane R
机构信息
National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA.
出版信息
Sex Transm Dis. 2006 Oct;33(10):610-3. doi: 10.1097/01.olq.0000216050.41305.c1.
OBJECTIVES
The objectives of this study were to determine whether women who douche regularly would enter a randomized trial of douching cessation or continuation, whether they would adhere to the assigned behavior, and whether there was a dramatic impact on vaginal flora.
GOAL
The goal of this study was to determine the feasibility of a large, definitive trial of douching cessation.
STUDY DESIGN
Women who douched at least weekly and who had either bacterial vaginosis or normal flora by Gram stain were assigned at random either to continue douching or to stop for 8 weeks. Vaginal Gram stains were obtained every 7 days from each woman.
RESULTS
Forty-eight women were randomized. Those assigned to continue reported douching during 77% of study weeks; those assigned to stop denied douching in 94% of weeks. No dramatic differences in flora were observed between women in the continue versus stop groups.
CONCLUSION
A large randomized trial of douching cessation is feasible.
目的
本研究的目的是确定经常进行阴道灌洗的女性是否会参与阴道灌洗停止或继续的随机试验，她们是否会坚持所分配的行为，以及对阴道菌群是否有显著影响。
目标
本研究的目标是确定一项大型、确定性的阴道灌洗停止试验的可行性。
研究设计
每周至少进行一次阴道灌洗且革兰氏染色显示患有细菌性阴道病或阴道菌群正常的女性被随机分配继续进行阴道灌洗或停止8周。每7天从每位女性获取阴道革兰氏染色样本。
结果
48名女性被随机分组。被分配继续灌洗的女性在77%的研究周内报告仍在进行灌洗；被分配停止灌洗的女性在94%的周内报告未进行灌洗。继续灌洗组和停止灌洗组女性的阴道菌群未观察到显著差异。
结论
一项大型的阴道灌洗停止随机试验是可行的。
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