Gentilcore Diana, Doran Selena, Meyer James H, Horowitz Michael, Jones Karen L
Department of Medicine, University of Adelaide, Royal Adelaide Hospital, South Australia, Australia.
Dig Dis Sci. 2006 Apr;51(4):652-6. doi: 10.1007/s10620-006-3187-y.
The aims of this study were to determine whether the hypotensive and heart rate responses to small intestinal glucose infusion are dependent on the glucose concentration. Eight healthy subjects, aged 65-78 years, were studied on 3 separate days in random order. Each subject received intraduodenal infusions of 50 g of glucose in either 300 mL (16.7%), 600 mL (8.3%), or 1200 mL (4.1%) of saline (0.9%) at a rate of 3 kcal/min for 60 minutes (t = 0-60 minutes), followed by saline (0.9%) for a further 60 minutes (t = 60-120 minutes). During the infusions, blood pressure (systolic and diastolic) and heart rate were measured every 3 minutes, and blood glucose concentrations every 15 minutes. Systolic and diastolic blood pressure fell (P < .0001), and heart rate and blood glucose increased (P = .0001 for both) over time, during all 3 infusions. Between t = -2-120 minutes, there was no difference in systolic blood pressure (P = .20), diastolic blood pressure (P = .61), or heart rate (P = .09) over the study days. There was also no significant difference in the glycemic response to the infusions. We conclude that in healthy older subjects, glucose concentration does not affect the blood pressure or heart rate responses to intraduodenal glucose and that, therefore, the magnitude of the postprandial fall in blood pressure induced by oral glucose is likely to depend primarily on the small intestinal glucose load.
本研究的目的是确定小肠输注葡萄糖时的降压和心率反应是否取决于葡萄糖浓度。八名年龄在65 - 78岁的健康受试者，于3个不同日期按随机顺序接受研究。每位受试者以3千卡/分钟的速率在60分钟内（t = 0 - 60分钟）经十二指肠输注50克葡萄糖，分别溶于300毫升（16.7%）、600毫升（8.3%）或1200毫升（4.1%）的生理盐水（0.9%）中，随后再输注60分钟的生理盐水（0.9%）（t = 60 - 120分钟）。在输注过程中，每3分钟测量一次血压（收缩压和舒张压）和心率，每15分钟测量一次血糖浓度。在所有3次输注过程中，随着时间推移，收缩压和舒张压均下降（P <.0001），心率和血糖均升高（两者P均 =.0001）。在t = -2 - 120分钟期间，各研究日的收缩压（P =.20）、舒张压（P =.61）或心率（P =.09）均无差异。输注后的血糖反应也无显著差异。我们得出结论，在健康老年受试者中，葡萄糖浓度不影响经十二指肠输注葡萄糖时的血压或心率反应，因此，口服葡萄糖引起的餐后血压下降幅度可能主要取决于小肠内的葡萄糖负荷。
