Sørensen Vigdis, Nilsen Trine, Wiedłocha Antoni
Department of Biochemistry, Institute for Cancer Research, The Norwegian Radium Hospital, University of Oslo, Norway.
Bioessays. 2006 May;28(5):504-14. doi: 10.1002/bies.20405.
Regulation of the subcellular localization of certain proteins is a mechanism for the regulation of their biological activities. FGF-2 can be produced as distinct isoforms by alternative initiation of translation on a single mRNA and the isoforms are differently sorted in cells. High molecular weight FGF-2 isoforms are not secreted from the cell, but are transported to the nucleus where they regulate cell growth or behavior in an intracrine fashion. 18 kDa FGF-2 can be secreted to the extracellular medium where it acts as a conventional growth factor by binding to and activation of cell-surface receptors. Furthermore, following receptor-mediated endocytosis, the exogenous FGF-2 can be transported to the nuclei of target cells, and this is of importance for the transmittance of a mitogenic signal. The growth factor is able to interact with several intracellular proteins. Here, the mode of action and biological role of intracellular FGF-2 are discussed.
某些蛋白质亚细胞定位的调控是调节其生物学活性的一种机制。FGF-2可通过在单个mRNA上的选择性翻译起始产生不同的异构体，这些异构体在细胞中的分选方式也不同。高分子量FGF-2异构体不会从细胞中分泌出来，而是被转运到细胞核，在那里它们以内分泌方式调节细胞生长或行为。18 kDa的FGF-2可分泌到细胞外介质中，通过与细胞表面受体结合并激活受体，作为一种传统的生长因子发挥作用。此外，在受体介导的内吞作用之后，外源性FGF-2可被转运到靶细胞的细胞核，这对于有丝分裂信号的传递很重要。这种生长因子能够与多种细胞内蛋白质相互作用。在此，将讨论细胞内FGF-2的作用方式和生物学作用。
