Center for Craniofacial Molecular Biology, Department of Biomedical Sciences, Ostrow School of Dentistry, University of Southern California, Los Angeles, CA, 90033, USA; Department of Biochemistry and Molecular Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
Center for Craniofacial Molecular Biology, Department of Biomedical Sciences, Ostrow School of Dentistry, University of Southern California, Los Angeles, CA, 90033, USA; Department of Biochemistry and Molecular Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
Differentiation. 2024 Sep-Oct;139:100733. doi: 10.1016/j.diff.2023.10.001. Epub 2023 Oct 12.
Fibroblast Growth Factor 2 (FGF2), also known as basic fibroblast growth factor, is a potent stimulator of growth and differentiation in multiple tissues. Its discovery traces back over 50 years ago when it was first isolated from bovine pituitary extracts due to its ability to stimulate fibroblast proliferation. Subsequent studies investigating the genomic structure of FGF2 identified multiple protein isoforms, categorized as the low molecular weight and high molecular weight FGF2. These isoforms arise from alternative translation initiation events and exhibit unique molecular and cellular functions. In this concise review, we aim to provide an overview of what is currently known about the structure, expression, and functions of the FGF2 isoforms within the contexts of development, homeostasis, and disease.
成纤维细胞生长因子 2（FGF2），也称为碱性成纤维细胞生长因子，是多种组织中生长和分化的有效刺激物。它的发现可以追溯到 50 多年前，当时它最初是从牛垂体提取物中分离出来的，因为它能够刺激成纤维细胞增殖。随后的研究调查了 FGF2 的基因组结构，确定了多个蛋白质同工型，分为低分子量和高分子量 FGF2。这些同工型是由不同的翻译起始事件产生的，表现出独特的分子和细胞功能。在这篇简明的综述中，我们旨在概述目前已知的 FGF2 同工型在发育、稳态和疾病中的结构、表达和功能。
