Hemandas A K, Salto-Tellez M, Maricar S H, Leong A F P K, Leow C K
National University Hospital, Singapore.
J Surg Oncol. 2006 May 1;93(6):498-503. doi: 10.1002/jso.20460.
Expression of S100A4, a small calcium-binding protein, in breast, oesophagus and gall bladder cancers is shown to be associated with adverse clinical outcome. We retrospectively examined the correlation of S100A4 expression and outcome in patients with colorectal cancer.
Tissue sections from 54 patients with Dukes B, C and D cancers operated on between 1995 and 1998 were stained with anti-S100A4 antibody. The S100A4 expression profile was correlated to the clinico-pathological details.
There were 31 males and 23 females (mean age 65.94 years +/- 12.29). Dukes stage, >4 positive lymph node status and S100A4 expression were significantly associated with poorer survival. The 3 years survival of patients whose tumour stained positive for S100A4 was 62.85% compared to 93.75% for those stained negative (P < 0.012). In patients with <4 involved nodes, S100A4 expression led to poorer survival (57 months vs. 74 months; P < 0.0052). Within a particular Dukes stage, S100A4 expression was associated with poorer outcome. The 5 years survival of Dukes B patients whose tumour stained negative for S100A4 was 92% compared to 54.6% for those with positive tumours.
Our results suggest that S100A4 expression is associated with adverse clinical outcome. Inclusion of S100A4 expression status may enhance our accuracy to prognosticate in patients with colorectal cancer.
小钙结合蛋白S100A4在乳腺癌、食管癌和胆囊癌中的表达与不良临床预后相关。我们回顾性研究了S100A4表达与结直肠癌患者预后的相关性。
对1995年至1998年间接受手术的54例Dukes B、C和D期癌症患者的组织切片用抗S100A4抗体进行染色。将S100A4表达谱与临床病理细节相关联。
患者中男性31例，女性23例（平均年龄65.94岁±12.29岁）。Dukes分期、4个以上阳性淋巴结状态和S100A4表达与较差的生存率显著相关。S100A4染色阳性的患者3年生存率为62.85%，而染色阴性的患者为93.75%（P<0.012）。在受累淋巴结少于4个的患者中，S100A4表达导致较差的生存率（57个月对74个月；P<0.0052）。在特定的Dukes分期内，S100A4表达与较差的预后相关。S100A4染色阴性的Dukes B期患者5年生存率为92%，而肿瘤阳性患者为54.6%。
我们的结果表明S100A4表达与不良临床预后相关。纳入S100A4表达状态可能提高我们对结直肠癌患者预后预测的准确性。
