Allgöwer Chantal, Kretz Anna-Laura, von Karstedt Silvia, Wittau Mathias, Henne-Bruns Doris, Lemke Johannes
Department of General and Visceral Surgery, Ulm University Hospital, Albert-Einstein-Allee 23, 89081 Ulm, Germany.
Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University Hospital Cologne, Weyertal 115b, 50931 Cologne, Germany.
Cancers (Basel). 2020 Jul 24;12(8):2037. doi: 10.3390/cancers12082037.
S100 proteins are widely expressed small molecular EF-hand calcium-binding proteins of vertebrates, which are involved in numerous cellular processes, such as Ca homeostasis, proliferation, apoptosis, differentiation, and inflammation. Although the complex network of S100 signalling is by far not fully deciphered, several S100 family members could be linked to a variety of diseases, such as inflammatory disorders, neurological diseases, and also cancer. The research of the past decades revealed that S100 proteins play a crucial role in the development and progression of many cancer types, such as breast cancer, lung cancer, and melanoma. Hence, S100 family members have also been shown to be promising diagnostic markers and possible novel targets for therapy. However, the current knowledge of S100 proteins is limited and more attention to this unique group of proteins is needed. Therefore, this review article summarises S100 proteins and their relation in different cancer types, while also providing an overview of novel therapeutic strategies for targeting S100 proteins for cancer treatment.
S100蛋白是脊椎动物中广泛表达的小分子EF手型钙结合蛋白，参与众多细胞过程，如钙稳态、增殖、凋亡、分化和炎症。尽管S100信号传导的复杂网络至今尚未完全破译，但几个S100家族成员与多种疾病有关，如炎症性疾病、神经疾病以及癌症。过去几十年的研究表明，S100蛋白在许多癌症类型（如乳腺癌、肺癌和黑色素瘤）的发生和发展中起着关键作用。因此，S100家族成员也被证明是有前景的诊断标志物和可能的新型治疗靶点。然而，目前对S100蛋白的了解有限，需要更多地关注这一独特的蛋白质群体。因此，这篇综述文章总结了S100蛋白及其在不同癌症类型中的关系，同时还概述了针对S100蛋白进行癌症治疗的新型治疗策略。
