Zhang Bin, Xu Zhen-Gang, Tang Ping-Zhang
Department of Head and Neck Surgery Cancer Hospital (Institute), Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, PR China.
J Surg Oncol. 2006 May 1;93(6):464-7. doi: 10.1002/jso.20478.
Despite the introduction of modern imaging techniques, it is still difficult to detect microscopic disease in neck nodes. The purpose of this study is to evaluate the efficacy of the lateral neck dissection (LND) for elective treatment of the clinically node negative neck (cN0) in laryngeal squamous cell carcinoma (SCC).
The clinical records of 110 cN0 patients with laryngeal SCC treated in this hospital from January 1997 to December 2002 were reviewed retrospectively.
One hundred ten patients received 145 elective LND. Occult metastasis was detected in 22 (20.0%) of this group of patients. The distribution of the 37 positive nodes was as follows: Level II 56.8%; Level III 37.8%; Level IV 5.4%. The 3-year neck recurrence rate estimated by the Kaplan-Meier approach for all cN0 patients (n = 110) was 5.4% [95% CI: 0.0%; 12.5%]. No significant difference in 3-year lymph node recurrence was found between node negative and node positive groups, between supraglottis and glottis groups, or between surgery alone and combined therapy groups.
The lateral neck dissection is effective in elective treatment of the neck in patients with laryngeal carcinoma.
尽管引入了现代成像技术，但检测颈部淋巴结的微小病变仍然困难。本研究的目的是评估选择性颈侧区清扫术（LND）对喉鳞状细胞癌（SCC）临床颈部淋巴结阴性（cN0）患者的治疗效果。
回顾性分析1997年1月至2002年12月在本院接受治疗的110例cN0喉鳞状细胞癌患者的临床记录。
110例患者接受了145次选择性颈侧区清扫术。在该组患者中，22例（20.0%）检测到隐匿性转移。37个阳性淋巴结的分布如下：Ⅱ区56.8%；Ⅲ区37.8%；Ⅳ区5.4%。采用Kaplan-Meier法估计所有cN0患者（n = 110）的3年颈部复发率为5.4% [95%可信区间：0.0%；12.5%]。在淋巴结阴性和阳性组之间、声门上区和声门区组之间或单纯手术组和联合治疗组之间，3年淋巴结复发率无显著差异。
颈侧区清扫术对喉癌患者颈部的选择性治疗有效。
