Hong Su Hyung, Kim Jung Wan, Kim Ho Gak, Park In Kyu, Ryoo Jun Wook, Lee Chang Hyeong, Sohn Yoon Kyung, Lee Jong Young
Department of Dental Microbiology, Kyungpook National University School of Dentistry.
J Prev Med Public Health. 2006 Mar;39(2):135-40.
Polymorphisms of genes from glutathione S-transferases (GSTs) and N-acetyltransferase 2 (NAT2) have been associated with increased susceptibility to various cancers. Previous results showed that East Asians such as Koreans, Japanese and Chinese have a much higher frequency of the GSTM1 and GSTT1 null genotypes and NAT2 rapid acetylator type. Therefore, we investigated the association between the polymorphic types of GSTs (GSTM1, GSTT1, GSTP1) and NAT2 and the incidence of gastric cancer which is one of the most prevalent cancers among the East Asians.
It was performed in a case-control study consisting of 238 healthy subjects and 108 cancer patients (54 distal and 54 proximal carcinomas). We also evaluated the association between GSTs and NAT2 and the risk factors for gastric cancer such as alcohol consumption, smoking, H. pylori infection, family history of gastric cancer, and tumor location.
In our study, the percentage of cases whose hometown was rural was higher than those of controls (odds ratio (OR) = 2.88; 95% CI = 1.72-4.76), and the frequency of the lower socio-economic status increased significantly in patients (OR = 2.53; 95% Cl = 1.59-4.02). There was no significant difference in the GST polymorphic types between the cases and controls. However, NAT2 rapid or intermediate acetylator types were frequently detected in the cases with family history of gastric cancer (OR = 1.92; 95% CI = 1.79-26.0).
These results suggest that the hometown and socio-economic status are important environmental factors for gastric carcinogenesis, and NAT2 polymorphic types could be associated with familial gastric carcinoma.
谷胱甘肽S-转移酶（GSTs）和N-乙酰转移酶2（NAT2）基因的多态性与多种癌症易感性增加有关。先前的研究结果表明，韩国人、日本人及中国人等东亚人群中GSTM1和GSTT1基因缺失型以及NAT2快速乙酰化型的频率要高得多。因此，我们研究了GSTs（GSTM1、GSTT1、GSTP1）和NAT2的多态性类型与胃癌发病率之间的关联，胃癌是东亚地区最常见的癌症之一。
本研究采用病例对照研究，纳入238名健康受试者和108名癌症患者（54例远端癌和54例近端癌）。我们还评估了GSTs和NAT2与胃癌风险因素之间的关联，如饮酒、吸烟、幽门螺杆菌感染、胃癌家族史和肿瘤位置。
在我们的研究中，病例组中来自农村的比例高于对照组（优势比（OR）=2.88；95%置信区间（CI）=1.72-4.76），且患者中社会经济地位较低的频率显著增加（OR = 2.53；95% CI = 1.59-4.02）。病例组和对照组之间GST多态性类型没有显著差异。然而，在有胃癌家族史的病例中，经常检测到NAT2快速或中间乙酰化型（OR = 1.92；95% CI = 1.79-26.0）。
这些结果表明，籍贯和社会经济地位是胃癌发生的重要环境因素，NAT2多态性类型可能与家族性胃癌有关。
