Yolles S, Leafe T D, Meyer F J
J Pharm Sci. 1975 Jan;64(1):115-6. doi: 10.1002/jps.2600640124.
The timed-release of anticancer agents from composities with poly (lactic acid) was studied in rats. In the case of cyclophosphamide-poly (lactic acid) composites, 67% of the administered dose was released within 34 days. With cis-dichlorodiammineplatinum (II), the amount of drug released was only 9.3% within the same period. This difference might be attributed to the different solubilities of these two drugs in the polymer. Electron spectroscopy chemical analysis, a new tool, was used to investigate the extent of diffusion of drugs in polymer films.
在大鼠体内研究了抗癌剂从聚乳酸复合材料中的缓释情况。以环磷酰胺-聚乳酸复合材料为例，给药剂量的67%在34天内释放。对于顺式二氯二氨铂（II），在同一时期内药物释放量仅为9.3%。这种差异可能归因于这两种药物在聚合物中的溶解度不同。电子能谱化学分析作为一种新工具，用于研究药物在聚合物薄膜中的扩散程度。
