[喉切除术后咽皮瘘的预测性生化指标：一项临床研究]
[Predictive biochemical indicators of a postlaryngectomy pharyngocutaneous fistula: a clinical study].
作者信息
Martín Villares C, Pomar P, Iglesias M C, San Román J, Fernández Pello M, Aldama P, González Gimeno M J, Tapia M
机构信息
Servicio ORL, Hospital del Bierzo, Ponferrada, León.
出版信息
Acta Otorrinolaringol Esp. 2006 Mar;57(3):140-4. doi: 10.1016/s0001-6519(06)78679-4.
UNLABELLED
The aim of this clinical study was to determinate biochemical predictor indicators of postlaryngectomy pharyngocutaneous fistula.
PATIENTS AND METHODS
We have studied 100 patients with T2- 4 a laryngeal and piryform sinus carcinoma who underwent a laryngectomy. All patients were ASA 2-3. We studied serum albumin, protein serum level, cholesterol and lymphocites in each patient. These variables underwent statistical analysis (p < 0.05).
RESULTS
19% of the patients developed a postlaryngectomy pharyngocutaneous fistula, with a long-stay of 25 days vs. 10 days of stay in patients without postlaryngectomy pharyngocutaneous fistula. 7 postlaryngectomy pharyngocutaneous fistula needed surgical repair. Low serum albumin (< 3.5 g/dL) and a low level of serum proteins (< 6.5 g/dL) were predictive indicators of postlaryngectomy pharyngocutaneous fistula (p < 0.05).
CONCLUSIONS
Our results suggest that a low-level of serum proteins and albumin are predictive clinical parameters of postlaryngeal pharyngocutaneous fistula.
未标注
本临床研究的目的是确定喉切除术后咽皮瘘的生化预测指标。
患者与方法
我们研究了100例接受喉切除术的T2 - 4期喉癌和梨状窝癌患者。所有患者的美国麻醉医师协会（ASA）分级为2 - 3级。我们对每位患者的血清白蛋白、血清蛋白水平、胆固醇和淋巴细胞进行了研究。对这些变量进行了统计学分析（p < 0.05）。
结果
19%的患者发生了喉切除术后咽皮瘘，发生咽皮瘘的患者住院时间为25天，而未发生咽皮瘘的患者住院时间为10天。7例喉切除术后咽皮瘘需要手术修复。低血清白蛋白（< 3.5 g/dL）和低血清蛋白水平（< 6.5 g/dL）是喉切除术后咽皮瘘的预测指标（p < 0.05）。
结论
我们的结果表明，低血清蛋白和白蛋白水平是喉切除术后咽皮瘘的预测临床参数。
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