Wormser G P, Forseter G, Joline C, Tupper B, O'Brien T A
Department of Medicine, New York Medical College, Valhalla 10595.
Am J Infect Control. 1991 Oct;19(5):237-42. doi: 10.1016/s0196-6553(05)80255-x.
Many patients with human immunodeficiency virus (HIV) infection have also been infected with hepatitis C virus (HCV). To understand better the epidemiology of HCV infection in the health care setting, HCV antibody testing was done for 125 health care workers who had experienced parenteral exposures to blood of HIV-infected patients and for 33 control health care workers without such exposures. Of the 158 health care workers studied, two (1.3%) had positive tests for HCV, both on the baseline serum sample obtained at parenteral exposure. For the 98 exposed, seronegative health care workers who were prospectively followed, no HCV seroconversions were observed over a time of 17.6 +/- 16.9 months. At least 64 of these 98 health care workers were exposed to blood of HIV-infected intravenous drug users, a group with an HCV seroprevalence rate in excess of 50% at our center in suburban New York City. We conclude that parenteral exposure to blood of HIV-infected patients in the health care setting is rarely associated with the development of hepatitis C infection.
许多人类免疫缺陷病毒（HIV）感染者也感染了丙型肝炎病毒（HCV）。为了更好地了解医疗环境中HCV感染的流行病学情况，对125名曾通过非肠道途径接触过HIV感染患者血液的医护人员以及33名未接触过此类血液的对照医护人员进行了HCV抗体检测。在研究的158名医护人员中，有两人（1.3%）HCV检测呈阳性，均在非肠道接触时采集的基线血清样本检测中呈阳性。对于前瞻性随访的98名接触过但血清学阴性的医护人员，在17.6±16.9个月的时间内未观察到HCV血清学转换。这98名医护人员中至少有64人接触过HIV感染的静脉吸毒者的血液，在我们位于纽约市郊区的中心，该群体的HCV血清阳性率超过50%。我们得出结论，在医疗环境中通过非肠道途径接触HIV感染患者的血液很少会导致丙型肝炎感染。
