Odida Michael
Department of Pathology, Faculty of Medicine, Makerere University, Kampala, Uganda.
Afr Health Sci. 2005 Dec;5(4):291-4. doi: 10.5555/afhs.2005.5.4.291.
Non-glandular papillary carcinoma of the cervix are uncommon tumours. In Uganda where cervical carcinoma is very common, no cases of papillary squamous cell carcinoma of the cervix has been reported.
To ascertain the occurrence and describe the clinicopathological features of papillary squamous cell carcinoma of the cervix in Uganda.
Retrospective review of histologically diagnosed cases of squamous cell carcinoma of cervix with papillary structures.
Retrospective review of cases of cervical carcinoma diagnosed in the Pathology Department, Makerere University from 1968 to 1973 was done. Cases with features of squamous differentiation and forming papillary pattern were then selected.
Twenty cases were encountered and the ages of the patients ranged from 22 to 70 years (mean 46.6 years). Histologically, the tumours had thin to broad fibrovascular cores covered by multilayered squamous epithelium. In five cases, there were areas with very delicate fibrovascular cores covered by monolayered epithelial cells.
The results of this study show that in Uganda, papillary squamous cell carcinoma of the cervix does occur and is predominantly a disease of older women. The results also confirm that papillary squamous cell carcinoma is a distinct subtype with some variants, and support the hypothesis that squamous cell carcinoma of the cervix is heterogeneous group of tumuors.
宫颈非腺性乳头状癌是罕见肿瘤。在宫颈癌非常常见的乌干达，尚未有宫颈乳头状鳞状细胞癌的病例报道。
确定乌干达宫颈乳头状鳞状细胞癌的发生率并描述其临床病理特征。
对组织学诊断为具有乳头状结构的宫颈鳞状细胞癌病例进行回顾性研究。
对1968年至1973年在马凯雷雷大学病理科诊断的宫颈癌病例进行回顾性研究。然后选择具有鳞状分化特征并形成乳头状模式的病例。
共发现20例病例，患者年龄在22岁至70岁之间（平均46.6岁）。组织学上，肿瘤具有由多层鳞状上皮覆盖的薄至宽的纤维血管轴心。5例病例中，存在由单层上皮细胞覆盖的非常纤细的纤维血管轴心区域。
本研究结果表明，在乌干达，宫颈乳头状鳞状细胞癌确实存在，且主要是老年女性的疾病。结果还证实，乳头状鳞状细胞癌是一种具有一些变体的独特亚型，并支持宫颈癌是一组异质性肿瘤的假说。
