Lin Pei, Medeiros L Jeffrey, Yin C Cameron, Abruzzo Lynne V
Department of Hematopathology, M. D. Anderson Cancer Center, Box 72, The University of Texas, Houston, TX 77030, USA.
Cancer Genet Cytogenet. 2006 Apr 1;166(1):82-5. doi: 10.1016/j.cancergencyto.2005.10.007.
We identified a reciprocal translocation between chromosomes 3 and 8, with breakpoints at bands 3q26 and 8q24, in five patients with myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). The t(3;8)(q26;q24) was the sole cytogenetic aberration in two patients, was associated with trisomy 13 in one patient, and occurred with monosomy 7 in two patients. In three patients, the AML or MDS developed 36, 52, and 57 months following chemotherapy for soft tissue sarcoma, mantle cell lymphoma, and diffuse large B-cell lymphoma, respectively; in these three patients, the neoplasms were considered to be therapy-related. All five patients displayed marked trilineage dysplasia and variable degrees of cytopenias, with marked thrombocytosis noted in one patient and a normal platelet count in another patient. All patients were treated with combination chemotherapy; at writing, four were still alive and one had died during a follow-up period ranging from 1 to 16 months. We conclude that the t(3;8)(q26;q24) is a recurrent translocation associated with therapy-related MDS/AML or de novo AML, and is frequently associated with monosomy 7.
我们在5例骨髓增生异常综合征（MDS）或急性髓系白血病（AML）患者中发现了3号和8号染色体之间的相互易位，断点位于3q26和8q24带。t(3;8)(q26;q24)在2例患者中是唯一的细胞遗传学异常，在1例患者中与13号染色体三体相关，在2例患者中与7号染色体单体并存。3例患者分别在接受软组织肉瘤、套细胞淋巴瘤和弥漫性大B细胞淋巴瘤化疗后36、52和57个月发生AML或MDS；在这3例患者中，肿瘤被认为与治疗相关。所有5例患者均表现出明显的三系发育异常和不同程度的血细胞减少，1例患者有明显的血小板增多，另1例患者血小板计数正常。所有患者均接受联合化疗；撰写本文时，4例仍存活，1例在1至16个月的随访期内死亡。我们得出结论，t(3;8)(q26;q24)是一种与治疗相关的MDS/AML或原发性AML相关的复发性易位，且常与7号染色体单体相关。
