Schneider N R, Bowman W P, Frenkel E P
Department of Pathology, University of Texas Southwestern Medical Center, Dallas 75235-9072.
Ann Genet. 1991;34(3-4):256-63.
The authors report two cases of secondary myelodysplasia and acute myeloid leukemia with t(3;21)(q26.3;q22) as the only cytogenetic abnormality in neoplastic bone marrow. This translocation was identified as a rare, recurring, non-random aberration in chronic myeloid leukemia less than five years ago and in secondary acute myeloid leukemia and myelodysplasia in 1990. The known and suspected cases in the literature are reviewed.
作者报告了两例继发性骨髓发育异常和急性髓系白血病病例，其肿瘤性骨髓中唯一的细胞遗传学异常为t(3;21)(q26.3;q22)。这种易位在不到五年前被确定为慢性髓系白血病中一种罕见的、反复出现的、非随机的畸变，在1990年被确定为继发性急性髓系白血病和骨髓发育异常中的畸变。本文对文献中已知和疑似的病例进行了综述。
