Gonzalez-Juanatey Carlos, Amigo-Diaz Encarnacion, Miranda-Filloy Jose A, Testa Ana, Revuelta Javier, Garcia-Porrua Carlos, Martin Javier, Llorca Javier, Gonzalez-Gay Miguel A
Staff Physicians, Cardiology Division, Hospital Xeral-Calde, Lugo, Spain.
Semin Arthritis Rheum. 2006 Apr;35(5):333-9. doi: 10.1016/j.semarthrit.2005.12.002.
To assess the prevalence of echocardiographic and Doppler abnormalities in psoriatic arthritis (PsA) patients without clinically evident cardiovascular manifestations or classic atherosclerosis risk factors.
Fifty PsA patients were recruited from Hospital Xeral-Calde, Lugo, Spain. Patients seen during the period of recruitment that had classic cardiovascular risk factors or had suffered cardiovascular or cerebrovascular events were excluded. Fifty healthy matched controls were also studied. Echocardiographic and Doppler studies were performed in all cases and controls.
In PsA patients the frequency of aortic and tricuspid (10%) and mitral regurgitation (16%) was not different from that seen in matched controls (10, 4, and 12%). Also, the pulmonary artery systolic pressure was normal in the group of PsA patients (23.4+/-3.9 mm Hg). The prevalence of diastolic dysfunction, in all cases due to impaired relaxation, was similar in PsA patients (28%) and controls (24%) (P=0.65). In addition, no significant echocardiographic and Doppler differences were observed when PsA patients with polyarticular pattern were compared with the remaining PsA patients.
The present study shows that actively treated PsA patients without cardiovascular risk factors or clinically evident cardiovascular disease do not exhibit silent subclinical echocardiographic abnormalities.
评估无临床明显心血管表现或经典动脉粥样硬化危险因素的银屑病关节炎（PsA）患者超声心动图及多普勒异常的患病率。
从西班牙卢戈市的塞拉尔 - 卡尔德医院招募了50例PsA患者。排除在招募期间有经典心血管危险因素或曾发生心血管或脑血管事件的患者。还对50名健康匹配对照进行了研究。对所有病例和对照进行了超声心动图和多普勒检查。
在PsA患者中，主动脉瓣和三尖瓣反流（10%）以及二尖瓣反流（16%）的发生率与匹配对照（分别为10%、4%和12%）无差异。此外，PsA患者组的肺动脉收缩压正常（23.4±3.9 mmHg）。所有病例舒张功能障碍均由舒张功能减退引起，PsA患者（28%）和对照（24%）的患病率相似（P = 0.65）。此外，将多关节型PsA患者与其余PsA患者进行比较时，未观察到明显的超声心动图和多普勒差异。
本研究表明，无心血管危险因素或临床明显心血管疾病的积极治疗的PsA患者未表现出无症状的亚临床超声心动图异常。
