Johnson Sama, Summers Jeff, Pridmore Saxby
School of Psychology, University of Tasmania, Private Bag 30, Hobart 7001, Tasmania, Australia.
Pain. 2006 Jul;123(1-2):187-92. doi: 10.1016/j.pain.2006.02.030. Epub 2006 Apr 17.
Research has shown that transcranial magnetic stimulation (TMS) results in a transient reduction in the experience of chronic pain. The present research aimed to investigate whether a single session of high frequency TMS is able to change the sensory thresholds of individuals suffering from chronic pain. Detection and pain thresholds for cold and heat sensations were measured before and after 20Hz repetitive TMS (rTMS) administered over the motor cortex. A significant decrease in temperature for cold detection and pain thresholds and a significant increase in temperature for heat pain thresholds were evident following a single session of rTMS. In contrast, no change in detection and pain thresholds was obtained following sham rTMS. The finding that rTMS can have a direct effect on sensory thresholds in individuals suffering from chronic pain has implications for the therapeutic use of rTMS in the relief of chronic pain.
研究表明，经颅磁刺激（TMS）可使慢性疼痛体验暂时减轻。本研究旨在调查单次高频TMS是否能够改变慢性疼痛患者的感觉阈值。在运动皮层施加20Hz重复经颅磁刺激（rTMS）之前和之后，测量冷觉和热觉的检测阈值及疼痛阈值。单次rTMS后，冷觉检测和疼痛阈值的温度显著降低，热痛阈值的温度显著升高。相比之下，假rTMS后检测阈值和疼痛阈值没有变化。rTMS可对慢性疼痛患者的感觉阈值产生直接影响这一发现，对rTMS在缓解慢性疼痛中的治疗应用具有启示意义。
