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植物细胞中的铜辅因子传递

Copper cofactor delivery in plant cells.

作者信息

Pilon Marinus, Abdel-Ghany Salah E, Cohu Christopher M, Gogolin Kathryn A, Ye Hong

机构信息

Biology Department and Program in Molecular Plant Biology, Colorado State University, Fort Collins, Colorado 80523-1878, USA.

出版信息

Curr Opin Plant Biol. 2006 Jun;9(3):256-63. doi: 10.1016/j.pbi.2006.03.007. Epub 2006 Apr 17.

DOI:10.1016/j.pbi.2006.03.007
PMID:16616609
Abstract

Copper (Cu) is a micronutrient that has roles in photosynthesis, respiration, antioxidant activity, cell wall metabolism and hormone perception. Excess Cu is toxic and therefore its delivery has to be tightly regulated. Recent progress in the study of Cu homeostasis has revealed not only components of the Cu delivery machinery but also regulatory systems that control Cu-protein expression and coordinate the activity of Cu-delivery systems. The response of photosynthetic organisms to Cu deficiency indicates the existence of cross-talk between metal cofactor delivery pathways. Next to its well-established roles in plant metabolism, a novel function for Cu, first discovered in plants, is in the biogenesis of molybdenum cofactor. Defects in Cu delivery factors also suggest important roles for Cu in cell expansion.

摘要

铜(Cu)是一种微量元素,在光合作用、呼吸作用、抗氧化活性、细胞壁代谢和激素感知中发挥作用。过量的铜具有毒性,因此其传递必须受到严格调控。铜稳态研究的最新进展不仅揭示了铜传递机制的组成部分,还发现了控制铜蛋白表达并协调铜传递系统活性的调节系统。光合生物对铜缺乏的反应表明金属辅因子传递途径之间存在相互作用。除了在植物代谢中已确立的作用外,铜在植物中首次发现的一个新功能是参与钼辅因子的生物合成。铜传递因子的缺陷也表明铜在细胞扩张中具有重要作用。

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