Hirooka Yoshitaka
Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
Auton Neurosci. 2006 Jun 30;126-127:120-9. doi: 10.1016/j.autneu.2006.02.017. Epub 2006 Apr 17.
The arterial baroreceptor reflex is the major feedback control system that acts to stabilize blood pressure. Abnormalities of this reflex are considered to be an underlying mechanism in the cardiovascular diseases such as hypertension and heart failure. There is accumulating evidence, however, that central nervous system mechanisms are involved in the enhanced sympathetic drive that occurs in these disease states. This article reviews studies performed in our laboratory in which a gene transfer technique, in combination with other methods, was used to determine the functional role of the central control of cardiovascular regulation. We developed a technique to transfer adenovirus vectors encoding specific genes into the nucleus tractus solitarii (NTS) or the rostral ventral medulla (RVLM) of rats in vivo. We applied this technique to hypertensive rats as well as in mice with heart failure to explore the pathophysiological significance of nitric oxide, reactive oxygen species, and Rho-kinase.
动脉压力感受器反射是维持血压稳定的主要反馈控制系统。该反射异常被认为是高血压和心力衰竭等心血管疾病的潜在机制。然而，越来越多的证据表明，中枢神经系统机制参与了这些疾病状态下交感神经驱动增强的过程。本文综述了我们实验室进行的研究，其中采用基因转移技术并结合其他方法来确定心血管调节中枢控制的功能作用。我们开发了一种在体内将编码特定基因的腺病毒载体导入大鼠孤束核（NTS）或延髓头端腹外侧区（RVLM）的技术。我们将该技术应用于高血压大鼠以及心力衰竭小鼠，以探讨一氧化氮、活性氧和 Rho 激酶的病理生理意义。
