接受卵巢扭转手术的附件包块患者的新型血清炎症标志物。

Novel serum inflammatory markers in patients with adnexal mass who had surgery for ovarian torsion.

作者信息

Daponte Alexandros, Pournaras Spyros, Hadjichristodoulou Christos, Lialios Georgios, Kallitsaris Athanasios, Maniatis Antonios N, Messinis Ioannis E

机构信息

Department of Obstetrics and Gynaecology, University Hospital of Larissa, Larissa, Greece.

出版信息

Fertil Steril. 2006 May;85(5):1469-72. doi: 10.1016/j.fertnstert.2005.10.056. Epub 2006 Apr 17.

DOI:10.1016/j.fertnstert.2005.10.056

PMID:16616744

Abstract

OBJECTIVE

To determine the diagnostic value of preoperative levels of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), interleukin-8 (IL-8), and E-selectin in patients with an adnexal mass who had surgery for ovarian torsion.

DESIGN

Prospective study.

SETTING

University hospital.

PATIENT(S): Fifty consecutive women with adnexal mass who were admitted with a diagnosis of ovarian torsion.

INTERVENTION(S): All had a single preoperative measurement of IL-6, IL-8, TNF-alpha, and E-selectin by ELISA.

MAIN OUTCOME MEASURE(S): To determine if a single preoperative serum sampling of IL-6, IL-8, TNF-alpha, and E-selectin by ELISA can diagnose ovarian torsion.

RESULT(S): Thirteen patients had proven torsion of the ovary. Serum levels of IL-6 were significantly higher in the 13 patients with proven ovarian torsion compared with the 37 without ovarian torsion. Patients with IL-6 serum values > or =10.2 pg/mL had a 16 times higher risk of having ovarian torsion. No significant difference was found in TNF-alpha, IL-8, and E-selectin between the two groups.

CONCLUSION(S): The IL-6 levels might assist in the prompt diagnosis of ovarian torsion and allow a timely surgical intervention.

摘要