壶腹癌中MK-1表达作为手术切除后预后改善的预测指标

MK-1 expression in carcinoma of the ampulla of Vater as a predictor of improved prognosis after surgical resection.

作者信息

Hamada Yoshihiro, Nakayama Yoshifuku, Mizoguchi Mikiro, Ikeda Seiyo, Kuroki Masahide, Iwasaki Hiroshi

机构信息

Department of Pathology, School of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan.

出版信息

Cancer Lett. 2006 Nov 18;243(2):211-6. doi: 10.1016/j.canlet.2005.11.037. Epub 2006 Apr 17.

DOI:10.1016/j.canlet.2005.11.037

PMID:16616808

Abstract

This retrospective study investigated the prognostic significance of MK-1 expression in human carcinoma of the ampulla of Vater (CAV). Expression was examined immunohistochemically using specimens from 38 patients who underwent surgical treatment for CAV. Expression was found in 61% of samples. Thirteen of 15 well-differentiated but only two of eight poorly differentiated adenocarcinoma were positive (P=0.0352). MK-1 positivity tended to show significantly decreasing pT (P=0.0039), pN (P<or=0.001), and pStage (P=0.001). Multivariate analysis showed that MK-1 expression is an independent prognostic marker (P=0.0097) and Kaplan-Meier curves showed a significant relationship with increased overall survival (P=0.0137). These results suggest that MK-1 expression is a prognostic marker of CAV.

摘要

这项回顾性研究调查了MK-1表达在人类壶腹癌（CAV）中的预后意义。使用38例接受CAV手术治疗患者的标本进行免疫组织化学检查，以检测MK-1的表达情况。在61%的样本中发现有表达。15例高分化腺癌中有13例呈阳性，但8例低分化腺癌中只有2例呈阳性（P=0.0352）。MK-1阳性往往显示pT（P=0.0039）、pN（P≤0.001）和p分期（P=0.001）显著降低。多因素分析表明，MK-1表达是一个独立的预后标志物（P=0.0097），Kaplan-Meier曲线显示其与总生存率的提高存在显著关系（P=0.0137）。这些结果表明，MK-1表达是CAV的一个预后标志物。