不断前进：磷脂酰肌醇-4,5-二磷酸（PtdIns(4,5)P(2)）在细胞迁移中的作用

Movin' on up: the role of PtdIns(4,5)P(2) in cell migration.

作者信息

Ling Kun, Schill Nicholas J, Wagoner Matthew P, Sun Yue, Anderson Richard A

机构信息

Program in Molecular and Cellular Pharmacology, University of Wisconsin-Madison, Department of Pharmacology, University of Wisconsin Medical School, 1300 University Ave, Madison, WI 53706, USA.

出版信息

Trends Cell Biol. 2006 Jun;16(6):276-84. doi: 10.1016/j.tcb.2006.03.007. Epub 2006 Apr 17.

DOI:10.1016/j.tcb.2006.03.007

PMID:16616849

Abstract

Cell migration requires the coordination of many biochemical events, including cell-matrix contact turnover and cytoskeletal restructuring. Recent advances further implicate phosphatidylinositol(4,5)-bisphosphate [PtdIns(4,5)P(2)] in the control of these events. Many proteins that are crucial to the assembly of the migration machinery are regulated by PtdIns(4,5)P(2). Coordinated synthesis of PtdIns(4,5)P(2) at these sites is dependent on the precise targeting of the type I phosphatidylinositol phosphate kinases (PIPKs). Two PIPKI isoforms target to, and generate, PtdIns(4,5)P(2) at membrane ruffles and focal adhesions during cell migration. Here, we discuss our current understanding of PtdIns(4,5)P(2) in the regulation of cell responses to migratory stimuli and how the migrating cell controls PtdIns(4,5)P(2) availability.

摘要

细胞迁移需要协调许多生化事件，包括细胞与基质接触的更新以及细胞骨架的重塑。最近的进展进一步表明磷脂酰肌醇（4,5）-二磷酸[PtdIns(4,5)P₂]参与这些事件的调控。许多对迁移机制组装至关重要的蛋白质受PtdIns(4,5)P₂调控。这些位点上PtdIns(4,5)P₂的协同合成依赖于I型磷脂酰肌醇磷酸激酶（PIPKs）的精确靶向作用。两种PIPKI同工型在细胞迁移过程中靶向并在膜皱褶和黏着斑处生成PtdIns(4,5)P₂。在此，我们讨论目前对PtdIns(4,5)P₂在调节细胞对迁移刺激反应方面的理解，以及迁移细胞如何控制PtdIns(4,5)P₂的可用性。