膜结合结构域
Membrane binding domains.
作者信息
Hurley James H
机构信息
Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA.
出版信息
Biochim Biophys Acta. 2006 Aug;1761(8):805-11. doi: 10.1016/j.bbalip.2006.02.020. Epub 2006 Mar 24.
Abstract
Eukaryotic signaling and trafficking proteins are rich in modular domains that bind cell membranes. These binding events are tightly regulated in space and time. The structural, biochemical, and biophysical mechanisms for targeting have been worked out for many families of membrane binding domains. This review takes a comparative view of seven major classes of membrane binding domains, the C1, C2, PH, FYVE, PX, ENTH, and BAR domains. These domains use a combination of specific headgroup interactions, hydrophobic membrane penetration, electrostatic surface interactions, and shape complementarity to bind to specific subcellular membranes.
摘要
真核生物信号传导和运输蛋白富含与细胞膜结合的模块化结构域。这些结合事件在空间和时间上受到严格调控。许多膜结合结构域家族的靶向作用的结构、生化和生物物理机制已经得到阐明。本综述对七大类膜结合结构域，即C1、C2、PH、FYVE、PX、ENTH和BAR结构域进行了比较分析。这些结构域通过特定的头部基团相互作用、疏水膜穿透、静电表面相互作用和形状互补相结合的方式，与特定的亚细胞膜结合。
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Use of EPR power saturation to analyze the membrane-docking geometries of peripheral proteins: applications to C2 domains.利用电子顺磁共振功率饱和分析外周蛋白的膜对接几何结构：应用于C2结构域。
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