DiNitto Jonathan P, Cronin Thomas C, Lambright David G
Program in Molecular Medicine and Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Sci STKE. 2003 Dec 16;2003(213):re16. doi: 10.1126/stke.2132003re16.
Modular domains that recognize and target intracellular membranes play a critical role in the assembly, localization, and function of signaling and trafficking complexes in eukaryotic cells. Large domain families, including PH, FYVE, PX, PHD, and C2 domains, combine specific, nonspecific, and multivalent interactions to achieve selective membrane targeting. Despite structural and functional diversity, general features of lipid recognition are evident in the various membrane-targeting mechanisms.
识别并靶向细胞内膜的模块化结构域在真核细胞中信号转导和运输复合体的组装、定位及功能方面发挥着关键作用。包括PH、FYVE、PX、PHD和C2结构域在内的大型结构域家族，通过特异性、非特异性和多价相互作用相结合来实现选择性膜靶向。尽管存在结构和功能多样性，但脂质识别的一般特征在各种膜靶向机制中都很明显。
