Costantini A, Luciani G, Annunziata G, Silvestri B, Branda F
Dipartimento di Ingegneria dei Materiali e della Produzione, Universitá di Napoli Federico II, Piazzale Tecchio, 80-80125 Napoli, Italy.
J Mater Sci Mater Med. 2006 Apr;17(4):319-25. doi: 10.1007/s10856-006-8230-1.
A novel hydrogel based on 2-hydroxyethyl- methacrilate and SiO(2) nanoparticles was prepared. The filler was added at a concentration of 30% w/w of silica nanoparticles to the mass of polymer. The composite material was characterised as far as concerns swelling behaviour in comparison to pHEMA. Swelling ratio of modified pHEMA was higher. Bioactivity of both SiO(2) nanoparticles and the modified hydrogel was evaluated by soaking samples into a simulated body fluid (SBF). FT-IR spectroscopy, scanning electron microscopy (SEM) and energy dispersive system (EDS) results suggest silica nanoparticles keep bioactive in the polymer. SiO(2) filler in a p(HEMA) matrix makes the composite bioactive. Therefore, these composites can be used to make bioactive scaffold for bone engineering.
制备了一种基于甲基丙烯酸2-羟乙酯和二氧化硅纳米颗粒的新型水凝胶。填料以二氧化硅纳米颗粒质量占聚合物质量30%（w/w）的浓度添加。就与聚甲基丙烯酸羟乙酯（pHEMA）相比的溶胀行为而言，对该复合材料进行了表征。改性pHEMA的溶胀率更高。通过将样品浸泡在模拟体液（SBF）中，评估了二氧化硅纳米颗粒和改性水凝胶的生物活性。傅里叶变换红外光谱（FT-IR）、扫描电子显微镜（SEM）和能量色散系统（EDS）结果表明，二氧化硅纳米颗粒在聚合物中保持生物活性。p（HEMA）基质中的二氧化硅填料使复合材料具有生物活性。因此，这些复合材料可用于制造骨工程用生物活性支架。
