Costa Ricardo O R, Pereira Marivalda M, Lameiras Fernando S, Vasconcelos Wander L
Centro de Desenvolvimento da Tecnologia Nuclear, CDTN/CNEN, Rua Prof. Mário Werneck, Campus da UFMG, Belo Horizonte, MG, Brazil, 30123-970.
J Mater Sci Mater Med. 2005 Oct;16(10):927-32. doi: 10.1007/s10856-005-4427-y.
Hybrids of poly(2-hydroxyethyl methacrylate) (PHEMA), a polymer that has been employed in a wide variety of biomedical applications, and silica-gel, which exhibits a well-known bioactivity, were produced. The obtained hybrids were characterized and their in vitro ability to induce the formation of a calcium phosphate layer on the surface was evaluated. The surface area of hybrids decreased with increasing amounts of PHEMA so that hybrids with more than approximately 40% PHEMA are virtually non-porous. All hybrids induced the formation of a calcium phosphate layer on their surfaces when soaked into simulated body fluid. The induction time and the morphology of the apatite layer varied according to the polymer content.
制备了聚甲基丙烯酸2-羟乙酯（PHEMA，一种已应用于多种生物医学领域的聚合物）与具有众所周知生物活性的硅胶的杂化物。对所得杂化物进行了表征，并评估了它们在体外诱导表面形成磷酸钙层的能力。杂化物的表面积随PHEMA含量的增加而减小，因此PHEMA含量超过约40%的杂化物实际上是无孔的。将所有杂化物浸泡在模拟体液中时，它们的表面均诱导形成了磷酸钙层。磷灰石层的诱导时间和形态因聚合物含量而异。
