Omura Yoshiaki
Heart Disease Research Foundation.
Acupunct Electrother Res. 2005;30(3-4):219-61. doi: 10.3727/036012905815901226.
The author evaluated the effects of DHEA (Dehydroepiandrosterone) on the amount of telomeres of normal cells and cancer cells and found the following: Contrary to the literature, which often recommended 25-50 mg of DHEA daily for the average adult human being, the author found that, depending on the individual, the maximum increase of normal cell telomere was obtained by a single optimal dose of 1.25-12.5 mg. This was examined in 50 people, both males and females, between the ages of 20-80 years old. When one optimal dose was given to each individual, the average telomere amount in normal tissues, measured in Bi-Digital O-Ring Test units, often increased from anywhere between 25-300 ng to between 500-530 ng. Cancer cell telomere reduced from higher than 1100 ng to less than 1 yg (=10(-24) g) with equally significant normalization of abnormal cancer parameters (such as Integrin alpha5beta1, Oncogen C-fosAb2, Acetylcholine, etc.). Circulatory improvement and an increase in grasping force of up to 25% were also detected, along with the changing of a few white hairs to black hairs. The beneficial effects of one optimal dose of DHEA generally lasted between 1 to 4 months, though in some individuals it lasted for a much shorter period of time due to a number of negative factors such as excessive stress/work, excessive exposure to low temperatures and toxic substances, or use of common pain medicines. On the other hand, if a patient took an excessive dose of DHEA, the amount of normal cell telomere decreased, while there was an increase in cancer cell telomere. It was found that those who took an overdose of 25-50 mg daily for more than 3 months had a high incidence of cancer of the prostate gland, breast, colon, lung, and stomach. Also, when the average normal cell telomere levels were less than 110 ng, compared with a normal value of 120-130 ng, and when DHEA in different parts of the body was also extremely low (less than 1-2 ng), one could suspect the possible presence of a malignant tumor somewhere in the body. When normal cell telomere was less than 110 ng, most individuals felt very weary with marked tiredness in the eyes, and grasping force was often reduced.
作者评估了脱氢表雄酮（DHEA）对正常细胞和癌细胞端粒数量的影响，结果如下：与文献中通常建议普通成年人每日服用25 - 50毫克DHEA相反，作者发现，因人而异，正常细胞端粒的最大增加量是通过1.25 - 12.5毫克的单次最佳剂量获得的。这在年龄介于20 - 80岁之间的50名男性和女性中进行了检测。当给每个人服用一次最佳剂量时，用双数字O形环测试单位测量，正常组织中的平均端粒量通常从25 - 300纳克之间的任何值增加到500 - 530纳克之间。癌细胞端粒从高于1100纳克减少到小于1微克（=10^(-24)克），同时异常癌症参数（如整合素α5β1、癌基因C - fosAb2、乙酰胆碱等）同样显著恢复正常。还检测到循环改善以及握力增加高达25%，同时有一些白发变黑发。一次最佳剂量的DHEA的有益效果通常持续1至4个月，不过在一些个体中，由于过度压力/工作、过度暴露于低温和有毒物质或使用普通止痛药等多种负面因素，其持续时间要短得多。另一方面，如果患者服用过量的DHEA，正常细胞端粒数量会减少，而癌细胞端粒会增加。发现那些每天过量服用25 - 50毫克超过3个月的人，患前列腺癌、乳腺癌、结肠癌、肺癌和胃癌的几率很高。此外，当正常细胞端粒水平平均低于110纳克（正常范围为120 - 130纳克），且身体不同部位的DHEA也极低（低于1 - 2纳克）时，就可能怀疑体内某处存在恶性肿瘤。当正常细胞端粒低于110纳克时，大多数人会感到非常疲倦，眼睛明显疲劳，握力也常常下降。
