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Regulation of Autophagy via Carbohydrate and Lipid Metabolism in Cancer.

作者信息

Alizadeh Javad, Kavoosi Mahboubeh, Singh Navjit, Lorzadeh Shahrokh, Ravandi Amir, Kidane Biniam, Ahmed Naseer, Mraiche Fatima, Mowat Michael R, Ghavami Saeid

机构信息

Department of Human Anatomy and Cell Science, College of Medicine, University of Manitoba, Winnipeg, MB R3E 0V9, Canada.

Department of Physiology and Pathophysiology, Rady Faculty of Health Sciences, Institute of Cardiovascular Sciences, Albrechtsen Research Centre, St. Boniface Hospital, Winnipeg, MB R2H 2A6, Canada.

出版信息

Cancers (Basel). 2023 Apr 7;15(8):2195. doi: 10.3390/cancers15082195.

DOI:10.3390/cancers15082195
PMID:37190124
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10136996/
Abstract

Metabolic changes are an important component of tumor cell progression. Tumor cells adapt to environmental stresses via changes to carbohydrate and lipid metabolism. Autophagy, a physiological process in mammalian cells that digests damaged organelles and misfolded proteins via lysosomal degradation, is closely associated with metabolism in mammalian cells, acting as a meter of cellular ATP levels. In this review, we discuss the changes in glycolytic and lipid biosynthetic pathways in mammalian cells and their impact on carcinogenesis via the autophagy pathway. In addition, we discuss the impact of these metabolic pathways on autophagy in lung cancer.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d87/10136996/aefa0749db71/cancers-15-02195-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d87/10136996/d7866fb7f02c/cancers-15-02195-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d87/10136996/41791e5a1b39/cancers-15-02195-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d87/10136996/ed4beb9d46e3/cancers-15-02195-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d87/10136996/33ec42253341/cancers-15-02195-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d87/10136996/22b4ed060655/cancers-15-02195-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d87/10136996/26e3eda2d9be/cancers-15-02195-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d87/10136996/584c44be3c95/cancers-15-02195-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d87/10136996/55e2bee84c25/cancers-15-02195-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d87/10136996/aefa0749db71/cancers-15-02195-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d87/10136996/d7866fb7f02c/cancers-15-02195-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d87/10136996/41791e5a1b39/cancers-15-02195-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d87/10136996/ed4beb9d46e3/cancers-15-02195-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d87/10136996/33ec42253341/cancers-15-02195-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d87/10136996/22b4ed060655/cancers-15-02195-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d87/10136996/26e3eda2d9be/cancers-15-02195-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d87/10136996/584c44be3c95/cancers-15-02195-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d87/10136996/55e2bee84c25/cancers-15-02195-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d87/10136996/aefa0749db71/cancers-15-02195-g009.jpg

相似文献

[1]
Regulation of Autophagy via Carbohydrate and Lipid Metabolism in Cancer.

Cancers (Basel). 2023-4-7

[2]
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[3]
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[4]
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[5]
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[6]
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[7]
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[8]
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[9]
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[10]
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Pharmacol Rep. 2019-8-14

引用本文的文献

[1]
Unlocking the lipid code: SREBPs as key drivers in gastrointestinal tumour metabolism.

Lipids Health Dis. 2025-5-24

[2]
Metabolic reprogramming in glioblastoma: a rare case of recurrence to scalp metastasis.

BJC Rep. 2025-4-24

[3]
Beyond Genetics: Exploring Lifestyle, Microbiome, and Social Determinants in Oral Cancer Development.

Cancers (Basel). 2025-3-25

[4]
Autophagy and Respiratory Viruses: Mechanisms, Viral Exploitation, and Therapeutic Insights.

Cells. 2025-3-12

[5]
Sex Disparity in Cancer: Role of Autophagy and Estrogen Receptors.

Cells. 2025-2-13

[6]
Autophagy induced by metabolic processes leads to solid tumor cell metastatic dormancy and recurrence.

Med Oncol. 2025-2-3

[7]
Fuel for thought: targeting metabolism in lung cancer.

Transl Lung Cancer Res. 2024-12-31

[8]
Lipids associated with autophagy: mechanisms and therapeutic targets.

Cell Death Discov. 2024-10-30

[9]
Unraveling the intricate relationship between lipid metabolism and oncogenic signaling pathways.

Front Cell Dev Biol. 2024-6-12

[10]
Downregulation of MYBL1 in endothelial cells contributes to atherosclerosis by repressing PLEKHM1-inducing autophagy.

Cell Biol Toxicol. 2024-5-27

本文引用的文献

[1]
Concise genetic profile of lung carcinoma.

Postgrad Med J. 2023-5-22

[2]
Biochemical Origin of the Warburg Effect in Light of 15 Years of Research Experience: A Novel Evidence-Based View (An Expert Opinion Article).

Onco Targets Ther. 2023-3-5

[3]
Experimental evidence and clinical implications of Warburg effect in the skeletal muscle of Fabry disease.

iScience. 2023-1-27

[4]
New Visions on Natural Products and Cancer Therapy: Autophagy and Related Regulatory Pathways.

Cancers (Basel). 2022-11-26

[5]
Clinical experience and management of adverse events in patients with advanced ALK-positive non-small-cell lung cancer receiving alectinib.

ESMO Open. 2022-12

[6]
Drug resistance mechanisms and progress in the treatment of EGFR-mutated lung adenocarcinoma.

Oncol Lett. 2022-9-26

[7]
Potential role of TGFΒ and autophagy in early crebellum development.

Biochem Biophys Rep. 2022-10-3

[8]
Differential impact of doxorubicin dose on cell death and autophagy pathways during acute cardiotoxicity.

Toxicol Appl Pharmacol. 2022-10-15

[9]
A collaborative workflow between pathologists and deep learning for the evaluation of tumour cellularity in lung adenocarcinoma.

Histopathology. 2022-12

[10]
FOXA1 prevents nutrients deprivation induced autophagic cell death through inducing loss of imprinting of IGF2 in lung adenocarcinoma.

Cell Death Dis. 2022-8-16

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