Alizadeh Javad, Kavoosi Mahboubeh, Singh Navjit, Lorzadeh Shahrokh, Ravandi Amir, Kidane Biniam, Ahmed Naseer, Mraiche Fatima, Mowat Michael R, Ghavami Saeid
Department of Human Anatomy and Cell Science, College of Medicine, University of Manitoba, Winnipeg, MB R3E 0V9, Canada.
Department of Physiology and Pathophysiology, Rady Faculty of Health Sciences, Institute of Cardiovascular Sciences, Albrechtsen Research Centre, St. Boniface Hospital, Winnipeg, MB R2H 2A6, Canada.
Cancers (Basel). 2023 Apr 7;15(8):2195. doi: 10.3390/cancers15082195.
Metabolic changes are an important component of tumor cell progression. Tumor cells adapt to environmental stresses via changes to carbohydrate and lipid metabolism. Autophagy, a physiological process in mammalian cells that digests damaged organelles and misfolded proteins via lysosomal degradation, is closely associated with metabolism in mammalian cells, acting as a meter of cellular ATP levels. In this review, we discuss the changes in glycolytic and lipid biosynthetic pathways in mammalian cells and their impact on carcinogenesis via the autophagy pathway. In addition, we discuss the impact of these metabolic pathways on autophagy in lung cancer.
代谢变化是肿瘤细胞进展的一个重要组成部分。肿瘤细胞通过改变碳水化合物和脂质代谢来适应环境压力。自噬是哺乳动物细胞中的一种生理过程，通过溶酶体降解来消化受损的细胞器和错误折叠的蛋白质，它与哺乳动物细胞的代谢密切相关，充当细胞ATP水平的衡量指标。在这篇综述中，我们讨论了哺乳动物细胞中糖酵解和脂质生物合成途径的变化及其通过自噬途径对致癌作用的影响。此外，我们还讨论了这些代谢途径对肺癌自噬的影响。
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