[通过24小时动态血压监测（ABPM）评估年轻的I型糖尿病正常血压患者的血压变化]

[Evaluation of blood pressure changes by 24-hours ambulatory blood pressure monitoring (ABPM) in young, normotensive patients with diabetes mellitus type I].

作者信息

Markuszewski Leszek, Ruxer Monika, Szadkowska Agnieszka, Bodalska Joanna, Bissinger Andrzej

机构信息

Uniwersytet Medyczny w Lodzi, Klinika Kardiologii Interwencyjnej i Kardiodiabetologii i Rehabilitacji Kardiologicznej I Katedry Kardiologii i Kardiochirurgii.

出版信息

Pol Merkur Lekarski. 2006 Jan;20(115):32-5.

PMID:16617731

Abstract

UNLABELLED

The aim of this study was to evaluate usefulness of ambulatory blood pressure monitoring (ABPM) to examine circadian patterns of blood pressure (BP) alterations in young, normotensive patients with type I diabetes mellitus (DM1).

MATERIAL AND METHODS

We studied 43 patients with DM1 aged 18-28 years, with 9-23 years of DM1, without long-term complications. Control group consisted of 32 healthy persons, matched to the DM1 group. 24h ABPM was performed by a Spacelab 90207 device to obtain daytime (7 AM to 11 PM, readings at 20-min interval) and nighttime (11 PM to 7 AM, readings at 30-min interval) measurements in both groups.

RESULTS

During the daytime systolic BP (sBP) and diastolic BP (dBP) were not significantly different from the control group. We noted nighttime sBP and dBP higher in DM1 group: sBE 119.7+/-12.6 mmHg vs. 103.817.1; p = 0.001 l dBP 65.5+/-6.2 vs. 61.5+/-3.1; p = 0.001. The loss of fall in BP ('non-dippers') was more prevalent in DM1 group: 49% vs. 9%; p = 0.003. Pulse pressure (PP) was significantly higher in DM1 patients: 50.9+/-6.9 mmHg vs. 44.8+/-5.6 mmHg; p = 0.0001.

CONCLUSIONS

ABPM is a useful method in detecting early BP alterations in young normotensive patients with diabetes mellitus type 4 1. Increased PP and suppressed diurnal BP variations could represent a increased risk of cardiovascular complications in young patients with diabetes mellitus type 1.

摘要

未标注

本研究的目的是评估动态血压监测（ABPM）在检查年轻的、血压正常的1型糖尿病（DM1）患者血压（BP）昼夜变化模式方面的实用性。

材料与方法

我们研究了43例年龄在18 - 28岁、患有DM1 9 - 23年且无长期并发症的患者。对照组由32名健康人组成，与DM1组匹配。两组均使用太空实验室90207设备进行24小时ABPM，以获取白天（上午7点至晚上11点，每隔20分钟读数一次）和夜间（晚上11点至上午7点，每隔30分钟读数一次）的测量值。

结果

白天收缩压（sBP）和舒张压（dBP）与对照组无显著差异。我们注意到DM1组夜间sBP和dBP较高：sBP为119.7±12.6 mmHg，而对照组为103.8±17.1；p = 0.001；dBP为65.5±6.2，而对照组为61.5±3.1；p = 0.001。血压下降消失（“非勺型”）在DM1组更为普遍：49%对9%；p = 0.003。DM1患者的脉压（PP）显著更高：50.9±6.9 mmHg对44.8±5.6 mmHg；p = 0.0001。