Zhao Zi-Ying, Zhao Zi-Yan, Wang Yue-Qiang, Yan Zhi-Hui, Cui Jian, Li Yu-Yang
School of Information Science and Engineering, Shandong University, Jinan, PR China.
Clin Exp Hypertens. 2005 Feb-Apr;27(2-3):187-94.
Ambulatory blood pressure monitoring (ABPM) recorded abundant data of BP and heart rate (HR) variations with even more derived parameters for evaluation of BP. Using our ABP database system established recently, we studied quantitatively the data of 24-hr ABP in Chinese. First, 155 Chinese were divided into three groups: 50 healthy subjects (C) of 20 men and 30 women, aged 60.0 +/- 10.3 (SD) years; 58 hypertensive patients (H, mild or moderate hypertension) of 33 men and 25 women, aged 59.4 +/- 8.0 years; 47 diabetes patients (D, type 2 diabetes, all were normotensive and with no insulin treatment) with 28 men and 19 women, aged 61.0 +/- 8.5 years. Then 24-hr ABP was monitored by TM-2421 Monitor and data were analyzed by ABP database, cosinor method, and conventional statistics. Our results were 4-fold: 1) systolic BP (SBP), diastolic BP (DBP), HR, rate-pressure product (HR x SBP) showed circadian variations, and significant circadian rhythms were confirmed by cosinor method in all groups. MESOR (midline estimate statistic of rhythm) differed significantly among three groups (H had the highest and C had the lowest values); 2) BP means (SBP, DBP, pulse pressure [PP], and HR x SBP) and BP loads (SBP, DBP, and PP) showed significant differences among the groups (H and D had higher values than that of C); 3) there were no significant differences of BP variability (BPV) of SBP, DBP, and PP among the groups; 4) areas under curve of BP (SBP, DBP, and PP) in H were significantly higher than in C and there was no significant difference between H and D. We concluded that ABPM can offer abundant information on BP evaluation by its direct recording data and derived parameters. The computerized way of treating the large numbers of ABPM values supplies a useful tool in evaluation of BP. Our results suggest that clinically normotensive diabetes patients had some pathological alterations in their BP systems.
动态血压监测（ABPM）记录了丰富的血压（BP）和心率（HR）变化数据以及更多用于评估血压的派生参数。利用我们最近建立的ABP数据库系统，我们对中国人群24小时ABP数据进行了定量研究。首先，将155名中国人分为三组：50名健康受试者（C组），其中男性20名，女性30名，年龄60.0±10.3（标准差）岁；58名高血压患者（H组，轻度或中度高血压），其中男性33名，女性25名，年龄59.4±8.0岁；47名糖尿病患者（D组，2型糖尿病，均血压正常且未接受胰岛素治疗），其中男性28名，女性19名，年龄61.0±8.5岁。然后用TM - 2421监测仪监测24小时ABP，并通过ABP数据库、余弦分析法和传统统计学方法对数据进行分析。我们的结果有四点：1）收缩压（SBP）、舒张压（DBP）、心率（HR）、率压积（HR×SBP）呈现昼夜变化，且通过余弦分析法在所有组中均证实有显著的昼夜节律。三组间的节律中线估计统计量（MESOR）差异显著（H组最高，C组最低）；2）血压均值（SBP、DBP、脉压[PP]和HR×SBP）以及血压负荷（SBP、DBP和PP）在各组间存在显著差异（H组和D组的值高于C组）；3）三组间SBP、DBP和PP的血压变异性（BPV）无显著差异；4）H组的血压（SBP、DBP和PP）曲线下面积显著高于C组，H组和D组之间无显著差异。我们得出结论，ABPM通过其直接记录的数据和派生参数能够提供有关血压评估的丰富信息。处理大量ABPM值的计算机化方法为血压评估提供了一个有用的工具。我们的结果表明，临床上血压正常的糖尿病患者其血压系统存在一些病理改变。
