Pazdiora P, Böhmová Z, Kubátová A, Menclová I, Morávková I, Průchová J, Prechová M, Spácilová M
Krajská hygienická stanice Plzenského kraje, Plzen.
Epidemiol Mikrobiol Imunol. 2006 Apr;55(2):53-8.
The study objectives were to identify HBsAg positive persons and to offer free vaccination against the infection to their family and sexual contacts found negative in screening for viral hepatitis B (VHB) postinfection markers.
Any person testing HBsAg positive in the Plzen region was registered in cooperation with laboratories. The collected data included reason for testing, clinical diagnosis and ethnicity. Contacts were screened for postinfection markers and vaccinated.
Between 1997 and 2004, 939 HBsAg positive persons were registered by laboratories in the Plzen region. Their mean age was 42.2 (0-90) years. As many as 63.4 % of the infected persons appeared to be "healthy" carriers. Nevertheless, a significant upward trend in HBsAg positivity was recorded among immigrants (mainly those from Vietnam). Altogether 18.2 % of 829 family and sexual contacts tested positive for VHB postinfection markers (HBsAg, anti-HBc). The highest percentages of infected contacts were detected among siblings and parents of HBsAg positive persons (36.5 % and 27.3 %, respectively). Free vaccination has been requested by 82.2 % of susceptible contacts.
Systematic vaccination of family and sexual contacts of HBsAg positive persons can contribute to more rapid VHB elimination in the Czech Republic. Currently, special attention in detecting infected persons is to be paid to immigrants from Asia.
本研究的目的是识别乙肝表面抗原(HBsAg)阳性者,并为其在乙肝病毒(VHB)感染后标志物筛查中呈阴性的家人和性接触者提供免费的乙肝疫苗接种。
在比尔森地区,与各实验室合作,对任何HBsAg检测呈阳性的人员进行登记。收集的数据包括检测原因、临床诊断和种族。对接触者进行感染后标志物筛查并接种疫苗。
1997年至2004年期间,比尔森地区的实验室登记了939名HBsAg阳性者。他们的平均年龄为42.2岁(0至90岁)。多达63.4%的感染者似乎是“健康”携带者。然而,在移民(主要是来自越南的移民)中,HBsAg阳性率呈显著上升趋势。在829名家人和性接触者中,共有18.2%的人VHB感染后标志物(HBsAg、抗-HBc)检测呈阳性。在HBsAg阳性者的兄弟姐妹和父母中,检测到的感染接触者比例最高(分别为36.5%和27.3%)。82.2%的易感接触者要求进行免费疫苗接种。
对HBsAg阳性者的家人和性接触者进行系统疫苗接种有助于在捷克共和国更快地消除VHB。目前,在检测感染者时应特别关注来自亚洲的移民。