Ogrin Rajna, Darzins Peteris, Khalil Zeinab
National Ageing Research Institute, The University of Melbourne, PO Box 31, Parkville, Victoria 3052, Australia.
Int Wound J. 2005 Sep;2(3):242-51. doi: 10.1111/j.1742-4801.2005.00122.x.
A new therapy using sensory nerve stimulation [International Patent Application Number PCT/AU2004/001079: "nerve function and tissue healing" (Khalil, Z)] has been developed in our vascular physiology laboratory. This treatment has been found to improve the deficient sensory nerve function and associated deficient wound healing of older persons to levels seen in young people. An 82-year-old man with a small but persistent venous leg ulcer for 18 months, despite apparently appropriate wound dressings and compression therapy, was seen in a specialist wound management service. The patient's sensory and microvascular function was assessed in great detail using the vascular physiology laboratory techniques, and he was provided the sensory nerve stimulation therapy in addition to conventional therapy. His wound healed after 4 weeks. We report the case here. Prior to nerve stimulation therapy, cutaneous sensation, microvascular blood flow and oxygen tension were found to be reduced near the ulcer when compared with the opposite, non ulcerated leg. After therapy, oxygen tension and microvascular blood flow had improved. This case provides further evidence that sensory nerve stimulation therapy at the stipulated parameters improves wound healing. The observation that sensory nerve function improved provides support for the notion that improvement in healing is mediated by improved nerve function.
我们的血管生理学实验室研发出了一种利用感觉神经刺激的新疗法[国际专利申请号PCT/AU2004/001079：“神经功能与组织愈合”(哈利勒，Z)]。现已发现，这种治疗方法能将老年人存在缺陷的感觉神经功能及相关的伤口愈合缺陷改善至年轻人的水平。一名82岁男性患有小腿静脉小溃疡，持续了18个月，尽管使用了看似合适的伤口敷料和压迫疗法，但仍在一家专业伤口管理机构接受治疗。运用血管生理学实验室技术对该患者的感觉和微血管功能进行了详细评估，并在常规治疗基础上为其提供了感觉神经刺激疗法。4周后他的伤口愈合。我们在此报告该病例。在进行神经刺激疗法之前，与对侧未溃疡的腿部相比，发现溃疡附近的皮肤感觉、微血管血流量和氧分压均降低。治疗后，氧分压和微血管血流量有所改善。该病例进一步证明，按规定参数进行感觉神经刺激疗法可促进伤口愈合。感觉神经功能得到改善这一观察结果支持了愈合改善是由神经功能改善介导的这一观点。
