Maqueda V M, Thijs V
Department of Neurology, University Hospitals Leuven, Leuven, Belgium.
Eur J Neurol. 2006 Mar;13(3):302-5. doi: 10.1111/j.1468-1331.2006.01211.x.
The outcome of cerebral venous thrombosis (CVT) has been studied infrequently. We assessed the frequency of recurrence of cerebral or systemic thromboembolism and factors influencing recurrence. We performed a retrospective study of consecutive patients with CVT in the period 1985-2002 who were admitted to the University Hospital Gasthuisberg. We performed a chart review and a semi-standardized telephone interview that focused on recurrent CVT or systemic thromboembolism. Fifty-four CVT patients with a mean age of 42 years were followed up for a mean of 3.5 years. Eighty percent were women. Coagulation disorders were found in 17 patients (31%). One patient (1.9%) had recurrent CVT and seven patients (12.9%) suffered systemic thromboembolism after a median of 2.5 months. Patients with recurrent thromboembolism more often had coagulopathies (P = 0.04) or a history of deep venous thrombosis (P = 0.007). Patients with early recurrent venous thromboembolism often were not treated with oral anticoagulants (P < 0.001). It was evident from the above study that a substantial number of patients suffer recurrent thromboembolism after CVT.
脑静脉血栓形成（CVT）的预后很少被研究。我们评估了脑或全身血栓栓塞复发的频率以及影响复发的因素。我们对1985年至2002年间入住加斯豪斯贝格大学医院的连续性CVT患者进行了一项回顾性研究。我们进行了病历审查和一次半标准化电话访谈，重点关注复发性CVT或全身血栓栓塞。54例平均年龄为42岁的CVT患者平均随访了3.5年。80%为女性。17例患者（31%）发现有凝血障碍。1例患者（1.9%）发生复发性CVT，7例患者（12.9%）在中位时间2.5个月后发生全身血栓栓塞。复发性血栓栓塞患者更常患有凝血障碍（P = 0.04）或有深静脉血栓形成病史（P = 0.007）。早期复发性静脉血栓栓塞患者常未接受口服抗凝剂治疗（P < 0.001）。从上述研究中可以明显看出，相当数量的患者在CVT后会发生复发性血栓栓塞。
