Department of Neurology, Stroke Program, Feinberg School of Medicine of Northwestern University, 710 North Lake Shore Drive, Abbott Hall 11th Floor, Chicago, IL 60611, USA.
Neurocrit Care. 2012 Apr;16(2):335-42. doi: 10.1007/s12028-011-9661-1.
Cerebral venous sinus thrombosis (CVST) often occurs in young patients and is treated with acute and then long-term oral anticoagulation. It is important to decide when to discontinue anticoagulation, as lifelong anticoagulation exposes the patient to considerable cumulative risk. However, a lack of high quality studies makes choosing a duration of anticoagulation after CVST difficult. In this article, we review the evidence for different treatment durations in several common clinical scenarios of CVST. In addition, when no direct evidence is available, we discuss and extrapolate from the more comprehensively studied situation of systemic venous thromboembolic disease. Recommendations are graded using standard criteria for the level of evidence.
脑静脉窦血栓形成（CVST）常发生于年轻患者，采用急性和长期口服抗凝治疗。决定何时停止抗凝非常重要，因为长期抗凝会使患者面临相当大的累积风险。然而，由于缺乏高质量的研究，使得选择 CVST 后抗凝的持续时间变得困难。在本文中，我们回顾了 CVST 几种常见临床情况下不同治疗持续时间的证据。此外，当没有直接证据时，我们从系统静脉血栓栓塞疾病这一研究更全面的情况进行讨论和推断。建议使用证据水平的标准标准进行分级。
