通向多特异性的多种途径。
Multiple paths to multispecificity.
作者信息
Mariuzza Roy A
机构信息
Center for Advanced Research in Biotechnology, W.M. Keck Laboratory for Structural Biology, University of Maryland Biotechnology Institute, Rockville, 20850, USA.
出版信息
Immunity. 2006 Apr;24(4):359-61. doi: 10.1016/j.immuni.2006.03.009.
PMID:16618592
Abstract
The limited primary antibody repertoire uses multiple mechanisms to account for the large number of potential antigens. In this issue of Immunity, Sethi et al. (2006) describe a new means for expanding the antibody repertoire, whereby a single antibody isomer binds diverse antigens at different regions of the binding site.
摘要
有限的初始抗体库利用多种机制来应对大量潜在抗原。在本期《免疫》杂志中，塞蒂等人（2006年）描述了一种扩展抗体库的新方法，即单一抗体异构体在结合位点的不同区域结合多种抗原。
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