Hong Se In, Cho Dong Hyeok, Kang Ho Cheol, Chung Dong Jin, Chung Min Young
Department of Internal Medicine, Chonnam National University Medical School, Japan.
Endocr J. 2006 Apr;53(2):255-8. doi: 10.1507/endocrj.53.255.
Corticosteroid treatment is frequently associated with psychiatric disturbances. These adverse effects are unusual with low dose of corticosteroid. We describe a patient who rapidly developed a steroid-induced psychosis with very low dose of prednisolone. A 48-year-old woman of Sheehan's syndrome was admitted to hospital with insomnia, euphoric moods and visual hallucinations. She had taken prednisolone (10 mg in the morning and 5 mg at night) for 6 days before admission. These symptoms appeared after first dose of prednisolone. A diagnosis of acute psychosis was made. After improvement of acute psychosis with discontinuation, re-administration of prednisolone at a dose of 2.5 mg per day gave rise to agitation and insomnia. She recovered completely by gradual dosage increase of short-acting corticosteroid after the discontinuation of prednisolone.
皮质类固醇治疗常伴有精神障碍。低剂量皮质类固醇出现这些不良反应的情况并不常见。我们描述了一名患者，使用极低剂量泼尼松龙后迅速出现类固醇诱导的精神病。一名患有席汉综合征的48岁女性因失眠、情绪欣快和视幻觉入院。入院前她服用泼尼松龙（早上10毫克，晚上5毫克）6天。这些症状在首次服用泼尼松龙后出现。诊断为急性精神病。停用泼尼松龙后急性精神病症状改善，但再次给予每日2.5毫克的泼尼松龙会引起躁动和失眠。停用泼尼松龙后通过逐渐增加短效皮质类固醇剂量，她完全康复。
